An NK2 receptor antagonist
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GR94800

Item No. 38773

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-benzoyl-L-alanyl-L-alanyl-D-tryptophyl-L-phenylalanyl-D-prolyl-L-prolyl-L-norleucinamide
CAS Number
141636-65-9
Synonyms
  • Benzoyl-Ala-Ala-trp-Phe-pro-Pro-Nle-NH2
  • GR98400
Molecular Formula
C49H61N9O8
Formula Weight
904.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
X-AAwFpPZ-NH2 (X = Benzoyl, Z = Norleucine)
Solubility(Learn about Variance in Solubility)
Acetonitrile: Soluble
SMILES
O=C(N[C@@H](CC1=CC=CC=C1)C(N2[C@@H](C(N3CCC[C@H]3C(N[C@@H](CCCC)C(N)=O)=O)=O)CCC2)=O)[C@H](NC([C@H](C)NC([C@H](C)NC(C4=CC=CC=C4)=O)=O)=O)CC5=CNC6=CC=CC=C56
InChi Code
InChI=1S/C49H61N9O8/c1-4-5-21-37(42(50)59)54-47(64)40-23-14-25-57(40)49(66)41-24-15-26-58(41)48(65)39(27-32-16-8-6-9-17-32)56-46(63)38(28-34-29-51-36-22-13-12-20-35(34)36)55-44(61)31(3)52-43(60)30(2)53-45(62)33-18-10-7-11-19-33/h6-13,16-20,22,29-31,37-41,51H,4-5,14-15,21,23-28H2,1-3H3,(H2,50,59)(H,52,60)(H,53,62)(H,54,64)(H,55,61)(H,56,63)/t30-,31-,37-,38+,39-,40-,41+/m0/s1
InChi Key
CWEISCOCKRHHOU-UJYVDGJVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $136

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    10 mg

    $256

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    25 mg

    $519

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    Product Description

    GR94800 is a synthetic peptide neurokinin-2 (NK2) receptor antagonist (Ki = 1 nM).1 It is selective for NK2 over NK3 (Ki = 1,000 nM). GR94800 (0.1 and 1 µM) decreases balloon distension-induced submaximal and maximal atropine-resistant ascending excitatory reflex (AER) in isolated guinea pig ileum circular muscles.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Antoniou, M., and Poulos, C. Analogues of the C-terminal fragments of neurokinins with modifications at their C-terminal methionyl residue. Structure-activity studies. Int. J. Pept. Protein Res. 43(4), 344-350 (1994).

    2. Maggi, C.A., Patacchini, R., Bartho, L., et al. Tachykinin NK1 and NK2 receptor antagonists and atropine-resistant ascending excitatory reflex to the circular muscle of the guinea-pig ileum. Br. J. Pharmacol. 112(1), 161-168 (1994).