An inhibitor of CSF1R
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Vimseltinib

Item No. 38783

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methyl-2-[(1-methylethyl)amino]-5-[6-methyl-5-[[2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]-2-pyridinyl]-4(3H)-pyrimidinone
CAS Number
1628606-05-2
Synonyms
  • DCC-3014
Molecular Formula
C23H25N7O2
Formula Weight
431.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
λmax
264, 335 nm
SMILES
CN1C=C(C2=CC(OC3=CC=C(C4=CN=C(NC(C)C)N(C4=O)C)N=C3C)=CC=N2)C=N1
InChi Code
InChI=1S/C23H25N7O2/c1-14(2)27-23-25-12-18(22(31)30(23)5)19-6-7-21(15(3)28-19)32-17-8-9-24-20(10-17)16-11-26-29(4)13-16/h6-14H,1-5H3,(H,25,27)
InChi Key
TVGAHWWPABTBCX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $51

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    10 mg

    $97

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    25 mg

    $215

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    50 mg

    $329

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    Product Description

    Vimseltinib is an inhibitor of colony stimulating factor 1 receptor (CSF1R; IC50 = 3.7 nM).1 It is selective for CSF1R over FMS-related tyrosine kinase 3 (FLT3), PDGFRα, PDGFRβ, and KIT (IC50s = >3,300, 436, 2,300, and 476 nM, respectively). Vimseltinib inhibits the proliferation of M-NFS-60 leukemia cells (IC50 = 18 nM). It inhibits CSF1-induced CFS1R autophosphorylation in THP-1 cells (IC50 = 27 nM) and CSF1- and RANKL-induced osteoclast differentiation (IC50 = 9.3 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Caldwell, T.M., Ahn, Y.M., Bulfer, S.L., et al. Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT). Bioorg. Med. Chem. Lett. 74, 128928 (2022).

    Product Citations

    Callahan, A., Zhang, X., Wang, A., et al. CSF1R-CAR T cells induce CSF1R signaling and can promote target cell proliferation. Sci. Signal. 18(912), eadv4112 (2025).