A CSF1R inhibitor
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ARRY-382

Item No. 38796

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-cyclopropyl-1-[(6-methyl-2-pyridinyl)methyl]-1H-indazol-4-yl]-7-[2-(4-methyl-1-piperazinyl)ethoxy]-imidazo[1,2-a]pyridine-3-carboxamide
CAS Number
1313407-95-2
Molecular Formula
C32H36N8O2
Formula Weight
564.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: Soluble
SMILES
O=C(C1=CN=C2C=C(C=CN21)OCCN3CCN(CC3)C)NC4=CC=CC5=C4C(C6CC6)=NN5CC7=CC=CC(C)=N7
InChi Code
InChI=1S/C32H36N8O2/c1-22-5-3-6-24(34-22)21-40-27-8-4-7-26(30(27)31(36-40)23-9-10-23)35-32(41)28-20-33-29-19-25(11-12-39(28)29)42-18-17-38-15-13-37(2)14-16-38/h3-8,11-12,19-20,23H,9-10,13-18,21H2,1-2H3,(H,35,41)
InChi Key
JUPOTOIJLKDAPF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    ARRY-382 is an inhibitor of the colony-stimulating factor 1 receptor (CSF1R; IC50 = 9 nM).1 It is selective for CSF1R over PDGFR, c-Kit, and FMS-related tyrosine kinase 3 (FLT3; IC50s = >10,000 nM for all). ARRY-382 (10 µM) induces apoptosis in several primary human chronic lymphocytic leukemia (CLL) cell lines. It also enhances the cytotoxicity of the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib (Item No. 16274) and PI3K p110δ inhibitor idelalisib (CAL-101; Item No. 15279) in several primary human CLL cell lines when used at concentrations ranging from 0.15625 to 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Edwards D.K., V., Sweeney, D.T., Ho, H., et al. Targeting of colony-stimulating factor 1 receptor (CSF1R) in the CLL microenvironment yields antineoplastic activity in primary patient samples. Oncotarget 9(37), 24576-24589 (2018).