An antimicrobial peptide and a derivative of LL-37
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OP-145 (trifluoroacetate salt)

Item No. 38841

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-isoleucylglycyl-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-lysyl-L-arginyl-L-isoleucyl-L-valyl-L-α-glutamyl-L-arginyl-L-isoleucyl-L-lysyl-L-arginyl-L-phenylalanyl-L-leucyl-L-arginyl-L-α-glutamyl-L-leucyl-L-valyl-L-arginyl-L-prolyl-L-leucyl-L-argininamide, trifluoroacetate salt
Synonyms
  • acetyl-IGKEFKRIVERIKRFLRELVRPLR-amide
  • P60.4-Ac
Molecular Formula
C142H246N46O31 • XCF3COOH
Formula Weight
3093.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
Ac-IGKEFKRIVERIKRFLRELVRPLR-NH2
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@H]1CCCN1C([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC([C@H](C(C)C)NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC(CNC([C@@]([C@H](CC)C)([H])NC(C)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.FC(F)(F)C(O)=O
InChi Code
InChI=1S/C142H246N46O31.C2HF3O2/c1-18-81(14)111(166-84(17)189)131(214)165-75-105(190)167-88(44-27-30-60-143)115(198)174-96(55-58-107(193)194)122(205)182-102(73-85-40-23-21-24-41-85)127(210)172-89(45-28-31-61-144)116(199)170-93(50-36-66-162-140(153)154)124(207)187-113(83(16)20-3)135(218)185-110(80(12)13)132(215)177-97(56-59-108(195)196)120(203)171-94(51-37-67-163-141(155)156)123(206)186-112(82(15)19-2)134(217)176-90(46-29-32-62-145)117(200)169-92(49-35-65-161-139(151)152)119(202)181-103(74-86-42-25-22-26-43-86)128(211)180-99(70-76(4)5)126(209)173-91(48-34-64-160-138(149)150)118(201)175-95(54-57-106(191)192)121(204)179-101(72-78(8)9)129(212)184-109(79(10)11)133(216)178-98(52-38-68-164-142(157)158)136(219)188-69-39-53-104(188)130(213)183-100(71-77(6)7)125(208)168-87(114(146)197)47-33-63-159-137(147)148;3-2(4,5)1(6)7/h21-26,40-43,76-83,87-104,109-113H,18-20,27-39,44-75,143-145H2,1-17H3,(H2,146,197)(H,165,214)(H,166,189)(H,167,190)(H,168,208)(H,169,200)(H,170,199)(H,171,203)(H,172,210)(H,173,209)(H,174,198)(H,175,201)(H,176,217)(H,177,215)(H,178,216)(H,179,204)(H,180,211)(H,181,202)(H,182,205)(H,183,213)(H,184,212)(H,185,218)(H,186,206)(H,187,207)(H,191,192)(H,193,194)(H,195,196)(H4,147,148,159)(H4,149,150,160)(H4,151,152,161)(H4,153,154,162)(H4,155,156,163)(H4,157,158,164);(H,6,7)/t81-,82-,83-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,109-,110-,111-,112-,113-;/m0./s1
InChi Key
KAAYBUZUNSPRGS-FCQSJDAQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    OP-145 is a synthetic antimicrobial peptide and derivative of the antimicrobial peptide LL-37 (Item No. 24461).1 It is active against E. coli, P. aeruginosa, C. albicans, and A. niger (MICs = 2, 3, 6, and 18 µM, respectively). Poly(lactic-co-glycolic acid) (PLGA) microspheres containing OP-145 prevent biofilm formation in a mouse model of bone infection induced by surgical femoral fracture followed by bacterial inoculation at the fracture site.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nell, M.J., Tjabringa, G.S., Wafelman, A.R., et al. Development of novel LL-37 derived antimicrobial peptides with LPS and LTA neutralizing and antimicrobial activities for therapeutic application. Peptides 27(4), 649-660 (2006).

    2. Cheng, Y., Qin, J., Huang, Y., et al. The antimicrobial effects of PLGA microspheres containing the antimicrobial peptide OP-145 on clinically isolated pathogens in bone infections. Sci. Rep. 12(1), 14541 (2022).