An inhibitor of the BRCA2-RAD51 protein-protein interaction
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Product Type

Biochemicals
Peptides

Research Area

Cancer
Cell Death
DNA Damage and Repair

BRC4wt (trifluoroacetate salt)

Item No. 38848

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-2-((5S,8S,11S,14S,17S,23S,26S)-14-((1H-imidazol-5-yl)methyl)-17-benzyl-11-((R)-1-hydroxyethyl)-5-(hydroxymethyl)-23,26-diisobutyl-8-methyl-4,7,10,13,16,19,22,25,28-nonaoxo-3,6,9,12,15,18,21,24,27-nonaazanonacosanamido)-6-amino-N-((5S,8S,11S,14S,17S,20S)-1,24-diamino-14-(4-aminobutyl)-11-((S)-sec-butyl)-5-carbamoyl-17-isopropyl-8-methyl-7,10,13,16,19-pentaoxo-6,9,12,15,18-pentaazatetracosan-20-yl)hexanamide, trifluoroacetate salt
Molecular Formula
C81H139N23O19 • XCF3COOH
Formula Weight
1739.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
Ac-LLGFHTASGKKVKIAK-NH2
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
NC([C@H](CCCCN)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC(CNC([C@H](CO)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@H](NC(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(C)=O)=O)=O)=O)CC1=CC=CC=C1)=O)CC2=CN=CN2)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C81H139N23O19.C2HF3O2/c1-13-47(8)66(80(122)91-48(9)69(111)96-54(68(86)110)27-17-21-31-82)103-75(117)57(30-20-24-34-85)98-79(121)65(46(6)7)102-74(116)56(29-19-23-33-84)97-73(115)55(28-18-22-32-83)94-63(108)40-89-72(114)62(42-105)101-70(112)49(10)92-81(123)67(50(11)106)104-78(120)61(38-53-39-87-43-90-53)100-77(119)60(37-52-25-15-14-16-26-52)95-64(109)41-88-71(113)58(35-44(2)3)99-76(118)59(36-45(4)5)93-51(12)107;3-2(4,5)1(6)7/h14-16,25-26,39,43-50,54-62,65-67,105-106H,13,17-24,27-38,40-42,82-85H2,1-12H3,(H2,86,110)(H,87,90)(H,88,113)(H,89,114)(H,91,122)(H,92,123)(H,93,107)(H,94,108)(H,95,109)(H,96,111)(H,97,115)(H,98,121)(H,99,118)(H,100,119)(H,101,112)(H,102,116)(H,103,117)(H,104,120);(H,6,7)/t47-,48-,49-,50+,54-,55-,56-,57-,58-,59-,60-,61-,62-,65-,66-,67-;/m0./s1
InChi Key
OQBACIUJSFOCAS-QTTULFAFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $128

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    10 mg

    $225

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    25 mg

    $492

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    Cayman Chemical
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    Product Description

    BRC4wt is an acetylated peptide derived from the BRC4 repeat in human BRCA2 (1521-1536) and an inhibitor of the protein-protein interaction between BRCA2 and RAD51.1 When coupled to the cationic cell-penetrating peptide (Arg)9 (Item No. 36714), BRC4wt shortens DNA replication tract lengths and reduces homologous repair frequency of DNA damage induced by the DNA topoisomerase I inhibitor camptothecin (Item No. 11694) in vitro, as well as potentiates cell death induced by the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib (Item No. 10621) in HeLa human cervical cancer and U2OS human osteosarcoma cells but not in non-cancerous hTERT RPE-1, MRC-5, or MCF-10A cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Trenner, A., Godau, J., and Sartori, A.A. A short BRCA2-derived cell-penetrating peptide targets RAD51 function and confers hypersensitivity toward PARP inhibition. Mol. Cancer Ther. 17(7), 1392-1404 (2018).