An active metabolite of obeticholic acid
Related Products
Alternative(s)
28243Tauro-Obeticholic Acid
Parent Compound(s)
110316-ECDCA
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Tauro-Obeticholic Acid (sodium salt)

Item No. 38878

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(3α,5β,6α,7α)-6-ethyl-3,7-dihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid, monosodium salt
CAS Number
2278141-79-8
Synonyms
  • Obeticholic Acid Taurine Conjugate
  • Tauro-OCA
  • Tauro-6-Ethyl-CDCA
  • Tauro-6-Ethylchenodeoxycholic Acid
  • T-ECDCA
Molecular Formula
C28H48NO6S • Na
Formula Weight
549.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 2 mg/ml
SMILES
CC[C@@H]1[C@]2([H])C[C@H](O)CC[C@]2(C)[C@]3([H])[C@@]([C@@](CC[C@]4([H])[C@@H](CCC(NCCS([O-])(=O)=O)=O)C)([H])[C@]4(C)CC3)([H])[C@@H]1O.[Na+]
InChi Code
InChI=1S/C28H49NO6S.Na/c1-5-19-23-16-18(30)10-12-28(23,4)22-11-13-27(3)20(7-8-21(27)25(22)26(19)32)17(2)6-9-24(31)29-14-15-36(33,34)35;/h17-23,25-26,30,32H,5-16H2,1-4H3,(H,29,31)(H,33,34,35);/q;+1/p-1/t17-,18-,19-,20-,21+,22+,23+,25+,26-,27-,28-;/m1./s1
InChi Key
FYNWRGZEJLGRGW-YIKLTSIESA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Tauro-obeticholic acid is an active metabolite of obeticholic acid, which is a farnesoid X receptor (FXR) agonist and semisynthetic derivative of chenodeoxycholic acid (Item No. 10011286).1,2 Tauro-obeticholic acid is formed from obeticholic acid by taurine conjugation in the liver but can be reconverted back to obeticholic acid by intestinal microflora.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Markham, A., and Keam, S.J. Obeticholic acid: First global approval. Drugs 76(12), 1221-1226 (2016).

    2. Li, X., Zhang, H., Li, C., et al. Comparison of the pharmacokinetics of generic versus branded obeticholic acid in a chinese population: Effects of food and sex. Clin. Pharmacol. Drug Dev. 10(7), 797-806 (2021).