A STING inhibitor
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SN-001

Item No. 38899

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-methoxyphenyl]-[1,1′-biphenyl]-4-carboxamide
CAS Number
727699-84-5
Synonyms
  • DUN99845
  • Stimulator of Interferon Genes Inhibitor 1
  • STING Inhibitor 1
Molecular Formula
C26H21FN2O4S
Formula Weight
476.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 5 mg/ml
SMILES
O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NC3=CC=C(C(NS(=O)(C4=CC=C(C=C4)F)=O)=C3)OC
InChi Code
InChI=1S/C26H21FN2O4S/c1-33-25-16-13-22(17-24(25)29-34(31,32)23-14-11-21(27)12-15-23)28-26(30)20-9-7-19(8-10-20)18-5-3-2-4-6-18/h2-17,29H,1H3,(H,28,30)
InChi Key
DVLMVJILWFSRPS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    SN-001 is an inhibitor of stimulator of interferon genes (STING).1 It inhibits herring testis DNA-induced Ifnb mRNA expression in L-929 cells (IC50 = 3.82 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hong, Z., Mei, J., Li, C., et al. STING inhibitors target the cyclic dinucleotide binding pocket. Proc. Natl. Acad. Sci. USA 118(24), e2105465118 (2021).