An inhibitor of mutant EGFR
Related Products
Enantiomer(s)
46085Sunvozertinib
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​(S)-Sunvozertinib

Item No. 38900

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[5-[[4-[[5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[(3S)-3-(dimethylamino)-1-pyrrolidinyl]-4-methoxyphenyl]-2-propenamide
CAS Number
2370013-49-1
Synonyms
  • T9304
Molecular Formula
C29H35ClFN7O3
Formula Weight
584.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Soluble
SMILES
CC(C)(O)C(C=C(C(Cl)=C1)F)=C1NC2=NC(NC3=CC(NC(C=C)=O)=C(N4CC[C@H](N(C)C)C4)C=C3OC)=NC=C2
InChi Code
InChI=1S/C29H35ClFN7O3/c1-7-27(39)34-22-14-23(25(41-6)15-24(22)38-11-9-17(16-38)37(4)5)35-28-32-10-8-26(36-28)33-21-13-19(30)20(31)12-18(21)29(2,3)40/h7-8,10,12-15,17,40H,1,9,11,16H2,2-6H3,(H,34,39)(H2,32,33,35,36)/t17-/m0/s1
InChi Key
BTMKEDDEMKKSEF-KRWDZBQOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    (S)-Sunvozertinib is an inhibitor of mutant EGFR and the enantiomer of sunvozertinib (Item No. 46085).1 It selectively inhibits the phosphorylation of EGFRL858R/T790M and EGFR containing exon 20 insertion (ex20ins) mutations, including EGFR ex20ins ASV and EGFR ex20ins NPH, over wild-type EGFR (IC50s = 1, 52, 51, and 362 nM, respectively). (S)-Sunvozertinib also inhibits the proliferation of PaTu 8988t pancreatic cancer cells (IC50 = 5.6 µM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, M., Yang, J.C., Mitchell, P.L., et al. Sunvozertinib, a selective EGFR inhibitor for previously treated non-small cell lung cancer with EGFR Exon 20 insertion mutations. Cancer Discov. 12(7), 1676-1689 (2022).