A dopamine uptake inhibitor
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GBR 13069 (hydrochloride)

Item No. 38903

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenyl-2-propen-1-yl)-piperazine, dihydrochloride
CAS Number
67469-45-8
Molecular Formula
C28H30F2N2O • 2HCl
Formula Weight
521.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/ml
λmax
254 nm
SMILES
FC1=CC=C(C(C2=CC=C(C=C2)F)OCCN3CCN(CC3)CC=CC4=CC=CC=C4)C=C1.Cl.Cl
InChi Code
InChI=1S/C28H30F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-15,28H,16-22H2;2*1H
InChi Key
ZBSZWEYIIGLGSX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $169

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    25 mg

    $401

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    Product Description

    GBR 13069 is a dopamine uptake inhibitor.1 It selectively inhibits dopamine uptake over norepinephrine uptake in rat occipital cortex slices (IC50s = 40 and 800 nM, respectively). GBR 13069 (2.5, 5, and 10 mg/kg) induces ipsilateral rotation and increases locomotion in rats. It also prevents 2’-CH3-MPTP-induced decreases in neostriatal levels of the endogenous catecholamine dopamine (Item No. 36532) and its metabolites DOPAC (3,4-dihydroxyphenylacetic acid; Item No. 24912) and homovanillic acid (HVA; Item No. 27307) in mice when administered at a dose of 5 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Heikkila, R.E., and Manzino, L. Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: Specific inhibitors of dopamine uptake. Eur. J. Pharmacol. 103(3-4), 241-248 (1984).

    2. Sonsalla, P.K., Youngster, S.K., Kindt, M.V., et al. Characteristics of 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the mouse. J. Pharmacol. Exp. Ther. 242(3), 850-857 (1987).