A cationic lipid
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1,2-Dioleoyl-3-trimethylammoniumpropane (methyl sulfate)

Item No. 38905

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N,N-trimethyl-2,3-bis[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-1-propanaminium, monomethyl sulfate
CAS Number
144189-73-1
Synonyms
  • DOTAP
Molecular Formula
C42H80NO4 • CH3SO4
Formula Weight
774.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleWater: Slightly soluble
SMILES
CCCCCCCC/C=C\CCCCCCCC(OC(C[N+](C)(C)C)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O.[O-]S(=O)(OC)=O
InChi Code
InChI=1S/C42H80NO4.CH4O4S/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;1-5-6(2,3)4/h20-23,40H,6-19,24-39H2,1-5H3;1H3,(H,2,3,4)/q+1;/p-1/b22-20-,23-21-;
InChi Key
RSMRWWHFJMENJH-LQDDAWAPSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

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    Product Description

    1,2-Dioleoyl-3-trimethylammoniumpropane (DOTAP) is a cationic liposome-forming compound used for transfection of DNA, RNA, and other negatively charged molecules into eukaryotic cells. It has been used in the composition of small unilamellar liposomes formulated as gene delivery vectors for gene therapy.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xiong, F., Mi, Z., and Gu, N. Cationic liposomes as gene delivery system: Transfection efficiency and new application. Pharmazie 66(3), 158-164 (2011).