A non-selective protein kinase inhibitor
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6-(Dimethylamino)purine

Item No. 38963

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-dimethyl-9H-purin-6-amine
CAS Number
938-55-6
Synonyms
  • N,N-Dimethyladenine
  • N6,N6-Dimethyladenine
  • 6-DMAP
  • NSC 401568
Molecular Formula
C7H9N5
Formula Weight
163.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 1 mg/ml
λmax
215, 276 nm
SMILES
CN(C)C1=C2NC=NC2=NC=N1
InChi Code
InChI=1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11)
InChi Key
BVIAOQMSVZHOJM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $33

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    Product Description

    6-(Dimethylamino)purine (6-DMAP) is a non-selective protein kinase inhibitor.1,2 It enhances the inactivation of MAPK and induces the formation of pronuclei in primary mouse oocytes.2,3 6-DMAP (0.6-12 mM) also induces pronuclear formation, cortical contraction, and cortical granule breakdown, markers of oocyte activation, in Xenopus oocytes.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vesely, J., Havlicek, J., Strnad, M., et al. Inhibition of cyclin-dependent kinases by purine analogues. Eur. J. Biochem. 224(2), 771-786 (1994).

    2. Lan, G.-C., Ma, S.-F., Wang, Z.-Y., et al. Effects of post-treatment with 6-dimethylaminopurine (6-DMAP) on ethanol activation of mouse oocytes at different ages. J. Exp. Zool. A Comp. Exp. Biol. 301(10), 837-843 (2004).

    3. Liu, L., and Yang, X. Interplay of maturation-promoting factor and mitogen-activated protein kinase inactivation during metaphase-to-interphase transition of activated bovine oocytes. Biol. Reprod. 61(1), 1-7 (1999).

    4. Zhang, S.C., and Masui, Y. Activation of Xenopus laevis eggs in the absence of intracellular Ca activity by the protein phosphorylation inhibitor, 6-dimethylaminopurine (6-DMAP). J. Exp. Zool. 262(3), 317-329 (1992).