A furanocoumarin with diverse biological activities
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Phellopterin

Item No. 38965

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-butyl-5-hydroxy-2-methyl-2-(4-methyl-3-penten-1-yl)-2H-1-benzopyran-6-carboxylic acid
CAS Number
2543-94-4
Synonyms
  • NSC 152469
Molecular Formula
C17H16O5
Formula Weight
300.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleMethanol: Soluble
SMILES
COC(C1=C2OC(C=C1)=O)=C(C=CO3)C3=C2OC/C=C(C)\C
InChi Code
InChI=1S/C17H16O5/c1-10(2)6-8-21-17-15-12(7-9-20-15)14(19-3)11-4-5-13(18)22-16(11)17/h4-7,9H,8H2,1-3H3
InChi Key
BMLZFLQMBMYVHG-UHFFFAOYSA-N
Origin
Plant/Saposhnikovia divaricata
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    Phellopterin is a furanocoumarin that has been found in A. dahurica and has diverse biological activities.1,2,3 It is an antagonist of GABAA receptors (IC50 = 360 nM for the rat receptor).1 Phellopterin (20 µM) decreases LPS-induced secretion of prostaglandin E2 (PGE2; Item No. 14010) from primary rat peritoneal macrophages.2 Topical application of phellopterin (1.2 µg/g) accelerates wound healing in a mouse model of diabetes induced by streptozotocin (Item No. 13104).3 It increases the levels of mRNA encoding sirtuin 1 (Sirt1) and decreases mRNA encoding intracellular adhesion molecule-1 (Icam-1) in epithelium isolated from mice in the same model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bergendorff, O., Dekermendjian, K., Nielsen, M., et al. Furanocoumarins with affinity to brain benzodiazepine receptors in vitro. Phytochemistry 44(6), 1121-1124 (1997).

    2. Ban, H.S., Lim, S.S., Suzuki, K., et al. Inhibitory effects of furanocoumarins isolated from the roots of Angelica dahurica on prostaglandin E2 production. Planta Med. 69(5), 408-412 (2003).

    3. Zou, J., Duan, Y., Wang, Y., et al. Phellopterin cream exerts an anti-inflammatory effect that facilitates diabetes-associated cutaneous wound healing via SIRT1. Phytomedicine 107, 154447 (2022).