Kurarinone

Kurarinone is a lavandulylated flavanone that has been found in S. flavescens and has diverse biological activities.^1,2,3,4 It inhibits COX-1 and 5-lipoxygenase (5-LO; IC₅₀s = 0.6-1 and 22 µM, respectively).¹ Kurarinone inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 cells (IC₅₀ = 26.6 µM).² It reduces potassium chloride- or norepinephrine-induced contractions in rat thoracic aortic helical strips when used at concentrations of 10 and 100 µM.³ In vivo, kurarinone (20 and 40 mg/kg) decreases disease severity and retinal neutrophil infiltration in a mouse model of experimental autoimmune uveitis induced by IRBP (1-20) (Item No. 36727).⁴

WARNING This product is not for human or veterinary use.

1. Chi, Y.S., Jong, H.G., Son, K.H., et al. Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: Cyclooxygenases and lipoxygenases. Biochem. Pharmacol. 62(9), 1185-1191 (2001).

2. Kwon, J., Basnet, S., Lee, J.W., et al. Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Bioorg. Med. Chem. Lett. 25(16), 3314-3318 (2015).

3. Yamahara, J., Kobayashi, G., Iwamoto, M., et al. Vasodilatory active principles of Sophora flavescens root. J. Ethnopharmacol. 29(1), 79-85 (1990).

4. Gu, C., Liu, Y., Lv, J., et al. Kurarinone regulates Th17/Treg balance and ameliorates autoimmune uveitis via Rac1 inhibition. J. Adv. Res. 69, 381-398 (2025).