A Certified Reference Material
Features
  • This product is qualified as a Certified Reference Material (CRM) that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This CRM has been characterized by metrologically valid procedures and may be used as a quantitative analytical reference standard
  • Certificate of analysis provides the certified property values and the associated uncertainties, including a statement of metrological traceability for the certified values
  • Bulk material is available for qualified institutions; please contact our sales department for pricing
Related Products
Analytical Standard(s)
21841Paynantheine
Isomer(s)
39879Isopaynantheine
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Paynantheine (CRM)

A 1 mg/ml solution in methanol

Item No. 38999

Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • (+)-Paynantheine
Technical Information
Formal Name
(αE,2S,3R,12bS)-3-ethenyl-1,2,3,4,6,7,12,12b-octahydro-8-methoxy-α-(methoxymethylene)-indolo[2,3-a]quinolizine-2-acetic acid, methyl ester
CAS Number
4697-66-9
Molecular Formula
C23H28N2O4
Formula Weight
396.5
Formulation (Request formulation change)
A 1 mg/ml solution in methanol
SMILES
COC1=CC=CC2=C1C3=C([C@@](C[C@H](/C(C(OC)=O)=C\OC)[C@@H](C=C)C4)([H])N4CC3)N2
InChi Code
InChI=1S/C23H28N2O4/c1-5-14-12-25-10-9-15-21-18(7-6-8-20(21)28-3)24-22(15)19(25)11-16(14)17(13-27-2)23(26)29-4/h5-8,13-14,16,19,24H,1,9-12H2,2-4H3/b17-13+/t14-,16-,19-/m0/s1
InChi Key
JGZKIGWXPPFMRG-CYSPOEIOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $329

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    Product Description

    Paynantheine (CRM) (Item No. 38999) is a certified reference material that is structurally similar to known opioids. Paynantheine is an alkaloid found in M. speciosa (Kratom in Thai).1 It has antinociceptive activity and reduces alcohol intake in rats.2,3 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Philipp, A.A., Wissenbach, D.K., Weber, A.A., et al. Metabolism studies of the Kratom alkaloids mitraciliatine and isopaynantheine, diastereomers of the main alkaloids mitragynine and paynantheine, in rat and human urine using liquid chromatography- linear ion trap- mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 879(15-16), 1049-1055 (2011).

    2. León, F., Obeng, S., Mottinelli, M., et al. Activity of Mitragyna speciosa ("Kratom") Alkaloids at Serotonin Receptors. J. Med. Chem. 64(18), 13510-13523 (2021).

    3. Gutridge, A.M., Robins, M.T., Cassell, R.J., et al. G protein-biased kratom-alkaloids and synthetic carfentanilamide opioids as potential treatments for alcohol use disorder. Br. J. Pharmacol. 177(7), 1497-1513 (2019).