An EP4 receptor antagonist
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AMX12006

Item No. 39027

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(1S)-1-[[[1-methyl-3-[[3-(trifluoromethyl)phenyl]amino]-1H-indol-2-yl]carbonyl]amino]ethyl]-benzoic acid
CAS Number
2639775-01-0
Molecular Formula
C26H22F3N3O3
Formula Weight
481.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
241 nm
SMILES
O=C(C1=C(NC2=CC(C(F)(F)F)=CC=C2)C(C=CC=C3)=C3N1C)N[C@@H](C)C4=CC=C(C(O)=O)C=C4
InChi Code
InChI=1S/C26H22F3N3O3/c1-15(16-10-12-17(13-11-16)25(34)35)30-24(33)23-22(20-8-3-4-9-21(20)32(23)2)31-19-7-5-6-18(14-19)26(27,28)29/h3-15,31H,1-2H3,(H,30,33)(H,34,35)/t15-/m0/s1
InChi Key
BBJLZNHEYIHTCB-HNNXBMFYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $65

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    5 mg

    $308

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    10 mg

    $520

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    Product Description

    AMX12006 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 (IC50 = 4.3 nM).1 It is selective for EP4 over EP1, EP2, and EP3 receptors (IC50s = >10 µM for all). AMX12006 is cytotoxic to MCF-7 and 4T1 breast and CT26 colon cancer cells (IC50s = 46.73, 79.47, and 41.39 µM, respectively). It reduces tumor volume alone or in combination with the 5-fluorouracil prodrug capecitabine (Item No. 10487) in CT26 murine colon cancer models when administered at a dose of 150 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Das, D., Qiao, D., Liu, Z., et al. Discovery of novel, selective prostaglandin EP4 receptor antagonists with efficacy in cancer models. ACS Med. Chem. Lett. 14(6), 727-736 (2023).