An amine-terminated PAMAM dendrimer
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PAMAM Dendrimer G1.0 Amine (water solution)

Item No. 39054

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1,N24-bis(2-aminoethyl)-4,21-bis[3-[(2-aminoethyl)amino]-3-oxopropyl]-11,14-bis[3-[[2-[bis[3-[(2-aminoethyl)amino]-3-oxopropyl]amino]ethyl]amino]-3-oxopropyl]-8,17-dioxo-4,7,11,14,18,21-hexaazatetracosanediamide
CAS Number
142986-44-5
Synonyms
  • PAMAM G1.0
  • Polyamidoamine Dendrimer G1.0
Molecular Formula
C62H128N26O12
Formula Weight
1429.9
Formulation (Request formulation change)
A 13.9% wt/wt solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C(CCN(CCC(NCCN)=O)CCNC(CCN(CCN(CCC(NCCN(CCC(NCCN)=O)CCC(NCCN)=O)=O)CCC(NCCN(CCC(NCCN)=O)CCC(NCCN)=O)=O)CCC(NCCN(CCC(NCCN)=O)CCC(NCCN)=O)=O)=O)NCCN
InChi Code
InChI=1S/C62H128N26O12/c63-13-21-71-51(89)1-33-83(34-2-52(90)72-22-14-64)45-29-79-59(97)9-41-87(42-10-60(98)80-30-46-84(35-3-53(91)73-23-15-65)36-4-54(92)74-24-16-66)49-50-88(43-11-61(99)81-31-47-85(37-5-55(93)75-25-17-67)38-6-56(94)76-26-18-68)44-12-62(100)82-32-48-86(39-7-57(95)77-27-19-69)40-8-58(96)78-28-20-70/h1-50,63-70H2,(H,71,89)(H,72,90)(H,73,91)(H,74,92)(H,75,93)(H,76,94)(H,77,95)(H,78,96)(H,79,97)(H,80,98)(H,81,99)(H,82,100)
InChi Key
QVWIZHOFYGKROL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 mg

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    Product Description

    PAMAM dendrimer G1.0 amine (PAMAM G1.0) is a polyamidoamine (PAMAM) dendrimer with amine termini that has been used as a drug delivery system in vitro.1 It is approximately 22 Å in diameter and has 8 surface groups.2 Micelles composed of PAMAM G1.0 conjugated to di-n-dodecylamine and encapsulating 5-fluorouracil (5-FU; Item No. 14416) increase the solubility of 5-FU and are cytotoxic to AGS gastric adenocarcinoma cells.1 PAMAM G1.0 conjugated to the clay mineral palygorskite (Pal-G1.0) on a PVDF membrane adsorbs the heavy metals nickel(II), cadmium(II), and copper(II) from aqueous solutions.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sarigul, E., Zaim, M., Senel, M., et al. Polyamidoamine dendron-bearing lipids as drug-delivery excipients. Molecules 27(22), 7817 (2022).

    2. Heiden, T.C., Dengler, E., Kao, W.J., et al. Developmental toxicity of low generation PAMAM dendrimers in zebrafish. Toxicol. Appl. Pharmacol. 225(1), 70-79 (2007).

    3. Zhang, X., Qin, Y., Zhang, G., et al. Preparation of PVDF/hyperbranched-nano-palygorskite composite membrane for efficient removal of heavy metal ions. Polymers (Basel) 11(1), 156 (2019).