A carboxylate-terminated PAMAM dendrimer
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PAMAM Dendrimer G0.5 Carboxylate (sodium salt) (water solution)

Item No. 39104

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11,14-bis[3-[[2-[bis(2-carboxyethyl)amino]ethyl]amino]-3-oxopropyl]-4,21-bis(2-carboxyethyl)-8,17-dioxo-4,7,11,14,18,21-hexaazatetracosanedioic acid, octasodium salt
CAS Number
339334-01-9
Synonyms
  • PAMAM G0.5 Carboxylate
  • Polyamidoamine Dendrimer G0.5 Carboxylate
Molecular Formula
C46H72N10O20 • 8Na
Formula Weight
1269.1
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C(NCCN(CCC([O-])=O)CCC([O-])=O)CCN(CCC(NCCN(CCC([O-])=O)CCC([O-])=O)=O)CCN(CCC(NCCN(CCC([O-])=O)CCC([O-])=O)=O)CCC(NCCN(CCC([O-])=O)CCC([O-])=O)=O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C46H80N10O20.8Na/c57-35(47-13-29-51(21-5-39(61)62)22-6-40(63)64)1-17-55(18-2-36(58)48-14-30-52(23-7-41(65)66)24-8-42(67)68)33-34-56(19-3-37(59)49-15-31-53(25-9-43(69)70)26-10-44(71)72)20-4-38(60)50-16-32-54(27-11-45(73)74)28-12-46(75)76;;;;;;;;/h1-34H2,(H,47,57)(H,48,58)(H,49,59)(H,50,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H,69,70)(H,71,72)(H,73,74)(H,75,76);;;;;;;;/q;8*+1/p-8
InChi Key
HLBBXYHSZWSLRS-UHFFFAOYSA-F
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

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    Product Description

    PAMAM dendrimer G0.5 carboxylate (PAMAM G0.5) is a polyamidoamine (PAMAM) dendrimer with carboxylate termini.1 It is approximately 27.9 Å in diameter in water and has 8 surface groups.2 Conjugates of PAMAM G0.5 with the active fragment of the DNA cross-linking agent oxaliplatin (Item No. 13106) are cytotoxic to A2780 ovarian, MCF-7 breast, and Caco-2 colon cancer cells and BJ fibroblasts (IC50s = 0.03, 1.6, 0.18, and 3 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Camacho, C., Tomás, H., and Rodrigues, J. Use of half-generation PAMAM dendrimers (G0.5-G3.5) with carboxylate end-groups to improve the DACHPtCl2 and 5-FU efficacy as anticancer drugs. Molecules 26(10), 2924 (2021).

    2. Caminati, G., Turro, N.J., and Tomalia, D.A. Photophysical investigation of starburst dendrimers and their interactions with anionic and cationic surfactants. J. Am. Chem. Soc. 112(23), 8515-8522 (1990).