A carboxylate-terminated PAMAM dendrimer
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PAMAM Dendrimer G1.5 Carboxylate (sodium salt) (water solution)

Item No. 39106

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
18,21-bis[3-[[2-[bis[3-[[2-[bis(2-carboxyethyl)amino]ethyl]amino]-3-oxopropyl]amino]ethyl]amino]-3-oxopropyl]-11,28-bis[3-[[2-[bis(2-carboxyethyl)amino]ethyl]amino]-3-oxopropyl]-4,35-bis(2-carboxyethyl)-8,15,24,31-tetraoxo-4,7,11,14,18,21,25,28,32,35-decaazaoctatriacontanedioic acid, hexadecasodium salt
CAS Number
251970-28-2
Synonyms
  • PAMAM G1.5 Carboxylate
  • Polyamidoamine Dendrimer G1.5 Carboxylate
Molecular Formula
C110H176N26O44 • 16Na
Formula Weight
2934.6
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C(CCN(CCC(NCCN(CCC([O-])=O)CCC([O-])=O)=O)CCNC(CCN(CCN(CCC(NCCN(CCC(NCCN(CCC([O-])=O)CCC([O-])=O)=O)CCC(NCCN(CCC([O-])=O)CCC([O-])=O)=O)=O)CCC(NCCN(CCC(NCCN(CCC([O-])=O)CCC([O-])=O)=O)CCC(NCCN(CCC([O-])=O)CCC([O-])=O)=O)=O)CCC(NCCN(CCC(NCCN(CCC([O-])=O)CCC([O-])=O)=O)CCC(NCCN(CCC([O-])=O)CCC([O-])=O)=O)=O)=O)NCCN(CCC([O-])=O)CCC([O-])=O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C110H192N26O44.16Na/c137-83(115-33-73-127(53-13-95(149)150)54-14-96(151)152)1-41-123(42-2-84(138)116-34-74-128(55-15-97(153)154)56-16-98(155)156)69-29-111-91(145)9-49-135(50-10-92(146)112-30-70-124(43-3-85(139)117-35-75-129(57-17-99(157)158)58-18-100(159)160)44-4-86(140)118-36-76-130(59-19-101(161)162)60-20-102(163)164)81-82-136(51-11-93(147)113-31-71-125(45-5-87(141)119-37-77-131(61-21-103(165)166)62-22-104(167)168)46-6-88(142)120-38-78-132(63-23-105(169)170)64-24-106(171)172)52-12-94(148)114-32-72-126(47-7-89(143)121-39-79-133(65-25-107(173)174)66-26-108(175)176)48-8-90(144)122-40-80-134(67-27-109(177)178)68-28-110(179)180;;;;;;;;;;;;;;;;/h1-82H2,(H,111,145)(H,112,146)(H,113,147)(H,114,148)(H,115,137)(H,116,138)(H,117,139)(H,118,140)(H,119,141)(H,120,142)(H,121,143)(H,122,144)(H,149,150)(H,151,152)(H,153,154)(H,155,156)(H,157,158)(H,159,160)(H,161,162)(H,163,164)(H,165,166)(H,167,168)(H,169,170)(H,171,172)(H,173,174)(H,175,176)(H,177,178)(H,179,180);;;;;;;;;;;;;;;;/q;16*+1/p-16
InChi Key
KKDVRAVJOOYSGF-UHFFFAOYSA-A
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    PAMAM dendrimer G1.5 carboxylate (PAMAM G1.5) is a polyamidoamine (PAMAM) dendrimer with carboxylate termini.1 It is approximately 36.2 Å in diameter in water and has 12 surface groups.2 PAMAM G1.5 (10 µM) inhibits plaque formation induced by Middle East respiratory syndrome coronavirus (MERS-CoV) in Vero cells.1 Conjugates of PAMAM G1.5 with the active fragment of the DNA cross-linking agent oxaliplatin (Item No. 13106) are cytotoxic to A2780 ovarian, MCF-7 breast, and Caco-2 colon cancer cells and BJ fibroblasts (IC50s = 0.04, 1.6, 0.3, and 1.3 µM, respectively).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kandeel, M., Al-Taher, A., Park, B.K., et al. A pilot study of the antiviral activity of anionic and cationic polyamidoamine dendrimers against the Middle East respiratory syndrome coronavirus. J. Med. Virol. 92(9), 1665-1670 (2020).

    2. Caminati, G., Turro, N.J., and Tomalia, D.A. Photophysical investigation of starburst dendrimers and their interactions with anionic and cationic surfactants. J. Am. Chem. Soc. 112(23), 8515-8522 (1990).

    3. Camacho, C., Tomás, H., and Rodrigues, J. Use of half-generation PAMAM dendrimers (G0.5-G3.5) with carboxylate end-groups to improve the DACHPtCl2 and 5-FU efficacy as anticancer drugs. Molecules 26(10), 2924 (2021).