A carboxylate-terminated PAMAM dendrimer
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PAMAM Dendrimer G3.5 Carboxylate (sodium salt) (water solution)

Item No. 39108

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
192948-77-9
Synonyms
  • PAMAM G3.5 Carboxylate
  • Polyamidoamine Dendrimer G3.5 Carboxylate
Molecular Formula
[NH2(CH2)2NH2]:(G=3.5);dendri PAMAM(NHCH2CH2COONa)64
Formula Weight
12927.7
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $237

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    1 g

    $450

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    Product Description

    PAMAM dendrimer G3.5 carboxylate (PAMAM G3.5) is a polyamidoamine (PAMAM) dendrimer with carboxylate termini that has been used as a drug delivery system in vitro and in vivo.1,2 It is approximately 66.1 Å in diameter in water and has 48 surface groups.3 PAMAM G3.5 is active against E. coli (IC50 = 22 mg/ml) and increases the mitochondrial membrane potential of isolated rat liver mitochondria when used at concentrations ranging from 10 to 50 µM.4,5 Unlike amine-terminated PAMAM G4.0, PAMAM G3.5 (20 µM) is not toxic to zebrafish embryos.6 A fluorescently labeled form of PAMAM G3.5 enters Caco-2 cells via dynamin-, clathrin-, and caveolin-mediated endocytosis.7 Conjugates of PAMAM G3.5 with the active fragment of the DNA cross-linking agent oxaliplatin (Item No. 13106) are cytotoxic to A2780 ovarian, MCF-7 breast, and Caco-2 colon cancer cells and BJ fibroblasts (IC50s = 0.08, 4.1, 0.39, and 3 µM, respectively).1 PAMAM G3.5 in complex with the topoisomerase I inhibitor camptothecin (Item No. 11694) increases the oral bioavailability of camptothecin in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Camacho, C., Tomás, H., and Rodrigues, J. Use of half-generation PAMAM dendrimers (G0.5-G3.5) with carboxylate end-groups to improve the DACHPtCl2 and 5-FU efficacy as anticancer drugs. Molecules 26(10), 2924 (2021).

    2. Sadekar, S., Thiagarajan, G., Bartlett, K., et al. Poly(amido amine) dendrimers as absorption enhancers for oral delivery of camptothecin. Int. J. Pharm. 456(1), 175-185 (2013).

    3. Caminati, G., Turro, N.J., and Tomalia, D.A. Photophysical investigation of starburst dendrimers and their interactions with anionic and cationic surfactants. J. Am. Chem. Soc. 112(23), 8515-8522 (1990).

    4. Wang, B., Navath, R.S., Menjoge, A.R., et al. Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers. Int. J. Pharm. 395(1-2), 298-308 (2010).

    5. Labieniec, M., and Gabryelak, T. Preliminary biological evaluation of poli(amidoamine) (PAMAM) dendrimer G3.5 on selected parameters of rat liver mitochondria. Mitochondrion 8(4), 305-312 (2008).

    6. Heiden, T.C., Dengler, E., Kao, W.J., et al. Developmental toxicity of low generation PAMAM dendrimers in zebrafish. Toxicol. Appl. Pharmacol. 225(1), 70-79 (2007).

    7. Goldberg, D.S., Ghandehari, H., and Swaan, P.W. Cellular entry of G3.5 poly (amido amine) dendrimers by clathrin- and dynamin-dependent endocytosis promotes tight junctional opening in intestinal epithelia. Pharm. Res. 27(8), 1547-1557 (2010).