A hydroxyl-terminated PAMAM dendrimer
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PAMAM Dendrimer G3.0 Amidoethanol (water solution)

Item No. 39112

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • PAMAM 3.0 Amidoethanol
  • Polyamidoamine Dendrimer G3.0 Amidoethanol
Molecular Formula
[NH2(CH2)2NH2]:(G=3);dendri PAMAM(NHCH2CH2OH)32
Formula Weight
6940.4
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: soluble
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $142

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    1 g

    $270

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    Product Description

    PAMAM dendrimer G3.0 amidoethanol (PAMAM G3.0 amidoethanol) is a polyamidoamine (PAMAM) dendrimer with hydroxyl termini.1 It is approximately 30 Å in diameter in PBS and has 32 surface groups. PAMAM G3.0 amidoethanol is an antagonist for the pore-forming channels anthrax protective antigen 63 (PA63) in lipid membranes (IC50 = 44.9 nM).2 It inhibits aggregation of amylin containing a serine-to-glycine substitution at position 20 (amylinS20G) in a concentration-dependent manner and amylinS20G-induced toxicity in MIN6-K8 and NIT-1 pancreatic β-cells at 6 µM.3 Topical application of PAMAM G3.0 amidoethanol (1 mg/ml) encapsulating the synthetic glucocorticoid dexamethasone (Item No. 11015) increases the levels of dexamethasone in the sclera, conjunctiva, and cornea in isolated rabbit eyes.4 It reduces tail growth in C. riparius larvae and induces DNA damage in a comet assay using C. riparius larval homogenates when used at concentrations of 10 or 100 ppm.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dobrovolskaia, M.A., Patri, A.K., Simak, J., et al. Nanoparticle size and surface charge determine effects of PAMAM dendrimers on human platelets in vitro. Mol. Pharm. 9(3), 382-393 (2012).

    2. Förstner, P., Bayer, F., Kalu, N., et al. Cationic PAMAM dendrimers as pore-blocking binary toxin inhibitors. Biomacromolecules 15(7), 2461-2474 (2014).

    3. Gurzov, E.N., Wang, B., Pilkington, E.H., et al. Inhibition of hIAPP amyloid aggregation and pancreatic β-cell toxicity by OH-terminated PAMAM dendrimer. Small 12(12), 1615-1626 (2016).

    4. Yavuz, B., Pehlivan, S.B., Vural, İ., et al. In vitro/in vivo evaluation of dexamethasone--PAMAM dendrimer complexes for retinal drug delivery. J. Pharm. Sci. 104(11), 3814-3823 (2015).

    5. Planelló, R., Rosal, R., Aquilino, M., et al. Genotoxic effects and transcriptional deregulation of genetic biomarkers in Chironomus riparius larvae exposed to hydroxyl- and amine-terminated generation 3 (G3) polyamidoamine (PAMAM) dendrimers. Sci. Total Environ. 774, 145828 (2021).