An inhibitor of influenza neuraminidases and an active metabolite of laninamivir octanoate
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Laninamivir

Item No. 39139

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid
CAS Number
203120-17-6
Synonyms
  • R-125489
Molecular Formula
C13H22N4O7
Formula Weight
346.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C)N[C@H]1[C@@]([C@H](OC)[C@H](O)CO)([H])OC(C(O)=O)=C[C@@H]1NC(N)=N
InChi Code
InChI=1S/C13H22N4O7/c1-5(19)16-9-6(17-13(14)15)3-8(12(21)22)24-11(9)10(23-2)7(20)4-18/h3,6-7,9-11,18,20H,4H2,1-2H3,(H,16,19)(H,21,22)(H4,14,15,17)/t6-,7+,9+,10+,11+/m0/s1
InChi Key
QNRRHYPPQFELSF-CNYIRLTGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

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    Product Description

    Laninamivir is an inhibitor of influenza neuraminidases and an active metabolite of the prodrug laninamivir octanoate (Item No. 40850).1 It inhibits the neuraminidases from influenza A H1N1, H2N2, and H3N2 strains (mean IC50s = 2.49, 11.4, and 16.7 nM, respectively) and influenza B Victoria and Yamagata strains (mean IC50s = 18.9 nM for both). Intranasal administration of laninamivir (69 µg/kg) increases survival in a mouse model of lethal influenza H1N1 infection. Formulations containing laninamivir have been used in the prevention of influenza.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamashita, M., Tomozawa, T., Kakuta, M., et al. CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity. Antimicrob. Agents Chemother. 53(1), 186-192 (2009).