An internal standard for the quantification of propionic acid
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Propionic Acid-d5

Item No. 39159

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
propanoic-d5 acid
CAS Number
60153-92-6
Synonyms
  • Propanoic Acid-d5
  • Propionate-d5
  • FA 3:0-d5
Molecular Formula
C3HD5O2
Formula Weight
79.1
Purity
≥99% deuterated forms (d1-d5)
Formulation
A neat oil
Solubility(Learn about Variance in Solubility)
Methanol: SolubleWater: Soluble
SMILES
[2H]C([2H])([2H])C([2H])([2H])C(O)=O
InChi Code
InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/i1D3,2D2
InChi Key
XBDQKXXYIPTUBI-ZBJDZAJPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $112

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    10 mg

    $212

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    25 mg

    $390

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    50 mg

    $556

    Add
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    Product Description

    Propionic acid-d5 is intended for use as an internal standard for the quantification of propionic acid by GC- or LC-MS. Propionic acid is a short-chain fatty acid.1 It is produced predominately by bacterial fermentation of dietary fiber in the colon but is also found in various dairy products such as yogurt.1,2 Propionic acid is an agonist of free fatty acid receptor 2 (FFAR2/GPR43) and FFAR3/GPR41.3 It inhibits forskolin-induced cAMP accumulation in CHO-K1 cells expressing FFAR2/GPR43 or FFAR3/GPR41 (EC50s = 14 and 6.2 µM, respectively) and induces chemotaxis of polymorphonuclear (PMN) neutrophils when used at a concentration of 1 mM. Propionic acid inhibits the proliferation of isolated mouse splenic B lymphocytes induced by concanavalin A (Item No. 14951) or LPS (IC50s = 6.6 and 4.6 mM, respectively).4 It is active against P. aeruginosa, E. coli, K. pneumoniae, and P. mirabilis when used at a concentration of 20 mM.5 Subgingival plaque levels of propionic acid are increased in patients with severe gingivitis.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, M., Wichienchot, S., He, X., et al. In vitro colonic fermentation of dietary fibers: Fermentation rate, short-chain fatty acid production and changes in microbiota. Trends Food Sci. Technol. 88(1), 1-9 (2019).

    2. Fernandez-Garcia, E., and McGregor, J.U. Determination of organic acids during the fermentation and cold storage of yogurt. J. Dairy Sci. 77(10), 2934-2939 (1994).

    3. Le Poul, E., Loison, C., Struyf, S., et al. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. The Journal of Biological Chemisty 278(28), 25481-24591 (2003).

    4. Kurita-Ochiai, T., Fukushima, K., and Ochiai, K. Volatile fatty acids, metabolic by-products of periodontopathic bacteria, inhibit lymphocyte proliferation and cytokine production. J. Dent. Res. 74(7), 1367-1373 (1995).

    5. Levison, M.E. Effect of colon flora and short-chain fatty acids on growth in vitro of Pseudomonas aeruginsoa and Enterobacteriaceae. Infect. Immun. 8(1), 30-35 (1973).

    6. Niederman, R., Buyle-Bodin, Y., Lu, B.Y., et al. Short-chain carboxylic acid concentration in human gingival crevicular fluid. J. Dent. Res. 76(1), 575-579 (1997).