An antagonist of yoda1-activated Piezo1
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Dooku1

Item No. 39161

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole
CAS Number
2253744-54-4
Molecular Formula
C13H9Cl2N3OS
Formula Weight
326.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
λmax
296 nm
SMILES
ClC1=CC=CC(Cl)=C1CSC2=NN=C(C3=CC=CN3)O2
InChi Code
InChI=1S/C13H9Cl2N3OS/c14-9-3-1-4-10(15)8(9)7-20-13-18-17-12(19-13)11-5-2-6-16-11/h1-6,16H,7H2
InChi Key
MNPOBXLPCWFONX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

    $193

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    25 mg

    $427

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    50 mg

    $800

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    Product Description

    Dooku1 is an antagonist of yoda1-activated Piezo1 ion channels (IC50 = 1.3 µM in HEK293 cells expressing the human receptor).1 It is selective for Piezo1 activated by yoda1 (Item No. 21904) over constituitively active Piezo1, transient receptor potential vanilloid 4 (TRPV4), and transient receptor potential canonical 4 (TRPC4) at 10 µM. Dooku1 (10 µM) reduces the percentage of cells with yoda1-induced extracellular phosphatidylserine exposure in red blood cells (RBCs) isolated from patients with sickle cell anemia.2 Preincubation with dooku1 (10 µM) inhibits yoda1-induced relaxation of isolated mouse aortic rings.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Evans, E.L., Cuthbertson, K., Endesh, N., et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br. J. Pharmacol. 175(10), 1744-1759 (2018).

    2. Wadud, R., Hannemann, A., Rees, D.C., et al. Yoda1 and phosphatidylserine exposure in red cells from patients with sickle cell anaemia. Sci. Rep. 10(1), 20110 (2020).