An inhibitor of ATM kinase
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A011

Item No. 39183

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-dimethyl-3-[[5-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazolo[4,5-c]quinolin-8-yl]-2-pyridinyl]oxy]-1-propanamine
CAS Number
3033712-80-7
Molecular Formula
C27H28N6O
Formula Weight
452.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): Slightly
λmax
234, 258, 305 nm
SMILES
CN(C)CCCOC1=NC=C(C2=CC=C(N=CC3=C4N([C@H](C)C5=CC=CC=C5)N=N3)C4=C2)C=C1
InChi Code
InChI=1S/C27H28N6O/c1-19(20-8-5-4-6-9-20)33-27-23-16-21(10-12-24(23)28-18-25(27)30-31-33)22-11-13-26(29-17-22)34-15-7-14-32(2)3/h4-6,8-13,16-19H,7,14-15H2,1-3H3/t19-/m1/s1
InChi Key
KAHMZYOZNYFPKN-LJQANCHMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $294

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    Product Description

    A011 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase (IC50 = 1 nM).1 It is selective for ATM over a panel of 408 additional kinases at 10 µM. A011 inhibits the growth of SW620 and HCT116 colorectal cancer cells (IC50s = 0.14 and 0.91 µM, respectively) and enhances cell death induced by DNA topoisomerase I inhibitor irinotecan (Item No. 14180) in the same cells when used at concentrations of 10, 30, and 100 nM. It also increases irradiation-induced cell death in SW620 cells. In vivo, A011 (5 mg/kg) increases irinotecan-induced reductions in tumor growth in an SW620 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, S., Zhou, P., Liu, J., et al. Discovery of [1,2,3]triazolo[4,5- c]quinoline derivatives as a new class of ataxia-telangiectasia mutated kinase inhibitors. ACS Med. Chem. Lett. 14(6), 746-756 (2023).