A polybrominated diphenyl ether
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BDE 47

Item No. 39232

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4-dibromo-1-(2,4-dibromophenoxy)-benzene
CAS Number
5436-43-1
Synonyms
  • NSC 21724
  • PBDE 47
  • 2,2',4,4'-Tetrabromodiphenyl ether
Molecular Formula
C12H6Br4O
Formula Weight
485.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
BrC1=CC(Br)=C(C=C1)OC2=CC=C(C=C2Br)Br
InChi Code
InChI=1S/C12H6Br4O/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6H
InChi Key
XYBSIYMGXVUVGY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    BDE 47 is a polybrominated diphenyl ether (PBDE).1 It increases liver and serum triglyceride levels in newborn pups when administered to pregnant mouse dams at a dose of 1 mg/kg per day.1 BDE 47 (20 µM) reduces the average speed and number of spontaneous movements in zebrafish.2 It decreases dorsal and ventral axon lengths and induces apoptosis in axial muscles in zebrafish at the same concentration. It has been found as a contaminant in human breast milk and livestock feed.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Khalil, A., Cevik, S.E., Hung, S., et al. Developmental exposure to 2,2',4,4'-tetrabromodiphenyl ether permanently alters blood-liver balance of lipids in male mice. Frontiers in Endocrinology 9(548), (2018).

    2. Chen, X., Huang, C., Wang, X., et al. BDE-47 disrupts axonal growth and motor behavior in developing zebrafish. Aquat. Toxicol. 120-121, 35-44 (2012).

    3. Thomsen, C., Haug, L.S., Stigum, H., et al. Changes in concentrations of perfluorinated compounds, polybrominated diphenyl ethers, and polychlorinated biphenyls in Norwegian breast-milk during twelve months of lactation. Environ. Sci. Technol. 44(24), 9550-9556 (2010).

    4. Chang, C.-J., Terrell, M.L., Marcus, M., et al. Serum concentrations of polybrominated biphenyls (PBBs), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in the Michigan PBB Registry 40 years after the PBB contamination incident. Environ. Int. 137, 105526 (2020).