A pentacyclic triterpene with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Taraxasterol

Item No. 39245

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,18α,19α)-urs-20(30)-en-3-ol
CAS Number
1059-14-9
Molecular Formula
C30H50O
Formula Weight
426.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Soluble
SMILES
C[C@]12[C@]3([C@@](CC[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC2)C)([H])[C@]5([H])[C@@](CC3)(CCC([C@H]5C)=C)C)C
InChi Code
InChI=1S/C30H50O/c1-19-11-14-27(5)17-18-29(7)21(25(27)20(19)2)9-10-23-28(6)15-13-24(31)26(3,4)22(28)12-16-30(23,29)8/h20-25,31H,1,9-18H2,2-8H3/t20-,21-,22+,23-,24+,25-,27-,28+,29-,30-/m1/s1
InChi Key
XWMMEBCFHUKHEX-ZJJHUPNDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $50

    Add

    5 mg

    $211

    Add

    10 mg

    $372

    Add

    25 mg

    $743

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Taraxasterol is a pentacyclic triterpene that has been found in T. mongolicum and has diverse biological activities.1,2,3 It decreases LPS-induced increases in the secreted levels of nitrite, prostaglandin E2 (PGE2; Item No. 14010), TNF-α, IL-1β, and IL-6 from RAW 264.7 macrophages when used at concentrations of 5 and 12.5 µg/ml.1 Taraxasterol reduces the levels of hepatitis B virus (HBV) surface antigen (HBsAg), HBV e antigen (HBeAg), and HBV DNA secreted from HBV-infected HepG2 2.2.15 hepatocytes in a concentration-dependent manner.2 In vivo, taraxasterol (10 mg/kg per day) prevents increases in liver damage, hepatocyte apoptosis, serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST), and hepatic levels of malondialdehyde (MDA), as well as decreases in the hepatic levels of glutathione (GSH), superoxide dismutase (SOD), and Bax in a mouse model of liver injury induced by the plant lectin concanavalin A (Item No. 14951).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, X., Xiong, H., and Liu, L. Effects of taraxasterol on inflammatory responses in lipopolysaccharide-induced RAW 264.7 macrophages. J. Ethnopharmacol. 141(1), 206-211 (2012).

    2. Yang, Y., Ying, G., Wu, S., et al. In vitro inhibition effects of hepatitis B virus by dandelion and taraxasterol. Infect. Agent. Cancer 15, 44 (2020).

    3. Sang, R., Yu, Y., Ge, B., et al. Taraxasterol from Taraxacum prevents concanavalin A-induced acute hepatic injury in mice via modulating TLRs/NF-κB and Bax/Bc1-2 signalling pathways. Artif. Cells Nanomed. Biotechnol. 47(1), 3929-3937 (2019).