A furanocoumarin with diverse biological activities
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Isomer(s)
197606’,7’-Epoxybergamottin
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Notopterol

Item No. 39268

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(2E)-5-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]oxy]-7H-furo[3,2-g][1]benzopyran-7-one
CAS Number
88206-46-6
Molecular Formula
C21H22O5
Formula Weight
354.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
C/C(CC(O)/C=C(C)/C)=C\COC1=C(C=CO2)C2=CC(O3)=C1C=CC3=O
InChi Code
InChI=1S/C21H22O5/c1-13(2)10-15(22)11-14(3)6-8-25-21-16-4-5-20(23)26-19(16)12-18-17(21)7-9-24-18/h4-7,9-10,12,15,22H,8,11H2,1-3H3/b14-6+
InChi Key
BKIACVAZUKISOR-MKMNVTDBSA-N
Origin
Plant/Hansenia weberbaueriana
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    Product Description

    Notopterol is a furanocoumarin originally isolated from H. weberbaueriana that has diverse biological activities.1,2,3 It is an inhibitor of JAK2 and JAK3 (IC50s = 9.51 and 25.2 µM, respectively) and is selective for JAK2 and JAK3 over tyrosine kinase 2 (TYK2) and JAK1 (IC50s = >667 and >2,000 µM, respectively).1 Notopterol (40 and 60µM) induces apoptosis and mitochondrial membrane depolarization in HL-60 leukemia cells.2 It induces cell cycle arrest at the G0/G1 phase in HL-60 cells when used at concentrations of 10, 20, and 40 µM. Notopterol (100 mg/kg) decreases acetic acid-induced writhing and vascular permeability in mice.3 It increases the duration of pentobarbital-induced sleep in mice when administered at doses of 10 or 30 mg/kg. In vivo, notopterol (20 mg/kg per day) reduces joint swelling, inhibits collagen-induced decreases in talus bone volume, and reduces the number of meniscus and talus osteoclasts in a mouse model of collagen-induced arthritis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, Q., Zhou, X., Yang, L., et al. The natural compound notopterol binds and targets JAK2/3 to ameliorate inflammation and arthritis. Cell Rep. 32(11), 108158 (2020).

    2. Huang, Q., Wang, L., Ran, Q., et al. Notopterol-induced apoptosis and differentiation in human acute myeloid leukemia HL-60 cells. Drug Des. Devel. Ther. 13, 1927-1940 (2019).

    3. Okuyama, E., Nishimura, S., Ohmori, S., et al. Analgesic component of Notopterygium incisum Ting. Chem. Pharm. Bull. (Tokyo) 41(5), 926-929 (1993).