An agonist of PPARγ
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XY-4

Item No. 39273

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
hexadecanoic acid, (1R)-2,2-difluoro-1-[(phosphonooxy)methyl]ethyl ester
CAS Number
474329-47-0
Molecular Formula
C19H37F2O6P
Formula Weight
430.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
FC([C@H](OC(CCCCCCCCCCCCCCC)=O)COP(O)(O)=O)F
InChi Code
InChI=1S/C19H37F2O6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(22)27-17(19(20)21)16-26-28(23,24)25/h17,19H,2-16H2,1H3,(H2,23,24,25)/t17-/m1/s1
InChi Key
FNESAIQQDLSXRX-QGZVFWFLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $218

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    Product Description

    XY-4 is a derivative of 1-palmitoyl-2-hydroxy-sn-glycero-3-PA (1-palmitoyl LPA; Item No. 10010094) and an agonist of peroxisome proliferator-activated receptor γ (PPARγ).1 It induces reporter gene expression in RAW 264.7 macrophages expressing a peroxisome proliferator-response element (PPRE) when used at a concentration of 5 µM. XY-4 does not act as an agonist at lysophosphatidic acid receptor 1 (LPA1), LPA2, or LPA3. It induces platelet aggregation in vitro when used at a concentration of 1 µM.2 XY-4 induces carotid artery neointima formation in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McIntyre, T.M., Pontsler, A.V., Silva, A.R., et al. Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist. Proc. Natl. Acad. Sci. USA 100(1), 131-136 (2003).

    2. Xu, Y., Qian, L., and Prestwich, G.D. Synthesis of monofluorinated analogues of lysophosphatidic acid. The Journal of Organic Chemistry 68(13), 5320-5330 (2003).

    3. Zhang, C., Baker, D.L., Yasuda, S., et al. Lysophosphatidic acid induces neointima formation through PPARγ activation. J. Exp. Med. 199(6), 763-774 (2004).