A PROTAC that drives STING degradation
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

STING PROTAC SP23

Item No. 39274

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-N1-[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-N4-[4-[[(5-nitro-2-furanyl)carbonyl]amino]phenyl]-2-butenediamide
CAS Number
2762552-74-7
Synonyms
  • PROTAC Stimulator of Interferon Genes Degrader-1
  • PROTAC STING Degrader-1
  • Proteolysis-targeting Chimera Stimulator of Interferon Genes Degrader-1
  • Proteolysis-targeting Chimera STING Degrader-1
  • Stimulator of Interferon Genes PROTAC SP23
  • Stimulator of Interferon Genes Proteolysis-targeting Chimera SP23
  • STING Proteolysis-targeting Chimera SP23
Molecular Formula
C34H33N7O10
Formula Weight
699.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Soluble
SMILES
O=C(N1C(CCC2=O)C(N2)=O)C(C(C1=O)=CC=C3)=C3NCCCCCCNC(/C=C/C(NC(C=C4)=CC=C4NC(C5=CC=C([N+]([O-])=O)O5)=O)=O)=O
InChi Code
InChI=1S/C34H33N7O10/c42-26(15-16-27(43)37-20-8-10-21(11-9-20)38-32(46)25-13-17-29(51-25)41(49)50)36-19-4-2-1-3-18-35-23-7-5-6-22-30(23)34(48)40(33(22)47)24-12-14-28(44)39-31(24)45/h5-11,13,15-17,24,35H,1-4,12,14,18-19H2,(H,36,42)(H,37,43)(H,38,46)(H,39,44,45)/b16-15+
InChi Key
TXNQXRGOKABDOB-FOCLMDBBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $149

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    STING PROTAC SP23 is a proteolysis-targeting chimera (PROTAC) containing the stimulator of interferon genes (STING) inhibitor C-170 (Item No. 30157) conjugated to the cereblon (CRBN) inhibitor pomalidomide (Item No. 19877) via an α,β-unsaturated carbonyl linker.1 It degrades STING in THP-1 cells with a half-maximal degradation concentration (DC50) of 3.2 µM, an effect that can be blocked by the proteasome inhibitor MG132 but not the lysosome inhibitor bafilomycin. STING PROTAC SP23 (2.5-20 µM) decreases cGAMP-induced increases in the levels of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells. It also reduces kidney weight, improves kidney function, and increases the survival rate in a mouse model of acute kidney injury induced by the DNA-crosslinking agent cisplatin (Item No. 13119) when administered at doses of 30 and 60 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, J., Yuan, L., Ruan, Y., et al. Novel CRBN-recruiting proteolysis-targeting chimeras as degraders of stimulator of interferon genes with in vivo anti-inflammatory efficacy. J. Med. Chem. 65(9), 6593-6611 (2022).