An endogenous peptide
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Product Type

Biochemicals
Peptides

Research Area

Cancer

Katacalcin (trifluoroacetate salt)

Item No. 39285

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-aspartyl-L-methionyl-L-seryl-L-seryl-L-α-aspartyl-L-leucyl-L-α-glutamyl-L-arginyl-L-α-aspartyl-L-histidyl-L-arginyl-L-prolyl-L-histidyl-L-valyl-L-seryl-L-methionyl-L-prolyl-L-glutaminyl-L-asparaginyl-L-alanyl-L-asparagine, trifluoroacetate salt
Synonyms
  • PDN-21
Molecular Formula
C97H154N34O36S2 • XCF3COOH
Formula Weight
2436.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
DMSSDLERDHRPHVSMPQNAN-OH
Solubility(Learn about Variance in Solubility)
Methanol: SolubleWater: Soluble
SMILES
[H]N[C@H](C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@H](C(N2CCC[C@H]2C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CC(N)=O)C(O)=O)=O)C)=O)=O)=O)=O)CCSC)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)CC4=CN=CN4)=O)CC(O)=O)=O)=O)=O)=O)CC(O)=[H]N[C@H](C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@H](C(N2CCC[C@H]2C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CC(N)=O)C(O)=O)=O)C)=O)=O)=O)=O)CCSC)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)CC4=CN=CN4)=O)CC(O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)CCSC)=O)CC(O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C97H154N34O36S2.C2HF3O2/c1-43(2)28-55(119-84(155)60(35-73(144)145)123-88(159)62(38-132)127-89(160)63(39-133)126-80(151)52(20-26-168-6)113-76(147)48(98)31-71(140)141)82(153)115-51(17-19-70(138)139)78(149)114-49(12-8-22-108-96(102)103)77(148)122-59(34-72(142)143)85(156)120-56(29-46-36-106-41-110-46)83(154)117-53(13-9-23-109-97(104)105)93(164)130-24-11-15-66(130)91(162)124-57(30-47-37-107-42-111-47)86(157)129-74(44(3)4)92(163)128-64(40-134)87(158)118-54(21-27-169-7)94(165)131-25-10-14-65(131)90(161)116-50(16-18-67(99)135)79(150)121-58(32-68(100)136)81(152)112-45(5)75(146)125-61(95(166)167)33-69(101)137;3-2(4,5)1(6)7/h36-37,41-45,48-66,74,132-134H,8-35,38-40,98H2,1-7H3,(H2,99,135)(H2,100,136)(H2,101,137)(H,106,110)(H,107,111)(H,112,152)(H,113,147)(H,114,149)(H,115,153)(H,116,161)(H,117,154)(H,118,158)(H,119,155)(H,120,156)(H,121,150)(H,122,148)(H,123,159)(H,124,162)(H,125,146)(H,126,151)(H,127,160)(H,128,163)(H,129,157)(H,138,139)(H,140,141)(H,142,143)(H,144,145)(H,166,167)(H4,102,103,108)(H4,104,105,109);(H,6,7)/t45-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,74-;/m0./s1
InChi Key
DCFGQXZPFVYDKA-YGEYRTRCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Katacalcin is an endogenous peptide (121-141) encoded by the CALCA gene and is expressed in, and secreted from, thyroid parafollicular cells in humans.1 Unlike calcitonin (Item No. 24409), a calcium regulating peptide hormone, katacalcin does not affect serum calcium levels. Plasma levels of katacalcin are increased in patients with medullary thyroid carcinoma.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fischer, J.A., and Born, W. Novel peptides from the calcitonin gene: Expression, receptors and biological function. Peptides 6(Suppl 3), 265-271 (1985).

    2. Takami, H., Shikata, J.-I., Horie, H., et al. PDN-21: Possible tumor marker for medullary thyroid carcinoma. J. Surg. Oncol. 44(4), 205-207 (1990).