A dual agonist of TLR7 and TLR8
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CL097

Item No. 39513

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(ethoxymethyl)-3H-imidazo[4,5-c]quinolin-4-amine
CAS Number
1026249-18-2
Molecular Formula
C13H14N4O
Formula Weight
242.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
248, 322 nm
SMILES
NC1=NC2=CC=CC=C2C3=C1N=C(COCC)N3
InChi Code
InChI=1S/C13H14N4O/c1-2-18-7-10-16-11-8-5-3-4-6-9(8)15-13(14)12(11)17-10/h3-6H,2,7H2,1H3,(H2,14,15)(H,16,17)
InChi Key
DEVCLHVFELRPIU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $33

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    5 mg

    $98

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    10 mg

    $181

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    25 mg

    $409

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    CL097 is a dual agonist of toll-like receptor 7 (TLR7) and TLR8.1 It induces activation of NF-κB in HEK293 cells expressing human TLR7 or TLR8 when used at concentrations of 0.1 and 1 µg/ml, respectively. CL097 induces TNF-α production and enhances LPS- or hyaluronic acid-induced TNF-α, IL-10, and IL-12 production in isolated human monocyte-derived macrophages.2 In vivo, CL097 (5 mg/kg) increases pancreatic lymph node IFN-α levels in pre-diabetic non-obese diabetic (NOD) mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schön, M.P., and Schön, M. TLR7 and TLR8 as targets in cancer therapy. Oncogene 27(2), 190-199 (2008).

    2. Petricevic, B., Wessner, B., Sachet, M., et al. CL097, a TLR7/8 ligand, inhibits TLR-4–dependent activation of IRAK-M and BCL-3 expression. Shock 32(5), 484-490 (2009).

    3. Lee, A.S., Ghoreishi, M., Cheng, W.K., et al. Toll-like receptor 7 stimulation promotes autoimmune diabetes in the NOD mouse. Diabetologia 54(6), 1407-1416 (2011).