A muscarinic DREADD agonist
Related Products
Isomer(s)
39532JHU37152
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

JHU37160

Item No. 39531

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-chloro-11-(4-ethyl-1-piperazinyl)-4-fluoro-5H-dibenzo[b,e][1,4]diazepine
CAS Number
2369979-68-8
Molecular Formula
C19H20ClFN4
Formula Weight
358.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly solubleWater: Slightly soluble
SMILES
FC1=CC=CC2=C1NC3=CC=C(Cl)C=C3N=C2N4CCN(CC4)CC
InChi Code
InChI=1S/C19H20ClFN4/c1-2-24-8-10-25(11-9-24)19-14-4-3-5-15(21)18(14)22-16-7-6-13(20)12-17(16)23-19/h3-7,12,22H,2,8-11H2,1H3
InChi Key
SWSCWOSASZXIRK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $41

    Add

    25 mg

    $97

    Add

    50 mg

    $163

    Add

    100 mg

    $266

    Add
    Product Description

    JHU37160 is an activator of designer receptors exclusively activated by designer drugs (DREADDs) derived from human muscarinic acetylcholine receptors (mAChRs).1 It binds to hM3Dq and hM4Di receptors (Kis = 1.9 and 3.6 nM, respectively) and induces Gαo1 activation in HEK293 cells expressing hM3Dq or hM4Di (EC50s = 18.5 and 0.2 nM, respectively). In vivo, JHU37160 (0.01-1 mg/kg) inhibits locomotor activity in D1-hM3Dq and D1-hM4Di transgenic mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bonaventura, J., Eldridge, M.A.G., Hu, F., et al. High-potency ligands for DREADD imaging and activation in rodents and monkeys. Nat. Commun. 10(1), 4627 (2019).