An amine-reactive reagent
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Sulfosuccinimidyl 3-[[2-(Biotinamido)ethyl]dithio]propionate (sodium salt)

Item No. 39537

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[2-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethyl]dithio]-propanoic acid, monosodium salt, 2,5-dioxo-3-sulfo-1-pyrrolidinyl ester
CAS Number
325143-98-4
Synonyms
  • Sulfo-NHS-SS-biotin
Molecular Formula
C19H27N4O9S4 • Na
Formula Weight
606.7
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solubleMethanol: Slightly soluble
SMILES
[H][C@]12NC(N[C@@](CS[C@H]2CCCCC(NCCSSCCC(ON3C(CC(S([O-])(=O)=O)C3=O)=O)=O)=O)1[H])=O.[Na+]
InChi Code
InChI=1S/C19H28N4O9S4.Na/c24-14(4-2-1-3-12-17-11(10-33-12)21-19(28)22-17)20-6-8-35-34-7-5-16(26)32-23-15(25)9-13(18(23)27)36(29,30)31;/h11-13,17H,1-10H2,(H,20,24)(H2,21,22,28)(H,29,30,31);/q;+1/p-1/t11-,12-,13?,17-;/m0./s1
InChi Key
IBKZNJXGCYVTBZ-IDBHZBAZSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Sulfosuccinimidyl 3-[[2-(biotinamido)ethyl]dithio]propionate (sulfo-NHS-SS-biotin) is a membrane-impermeable amine-reactive reagent that contains biotin (Item No. 22582) conjugated to N-hydroxysulfosuccinimide (sulfo-NHS; Item No. 20680) via a disulfide bond.1,2 It has been used as a derivatization reagent to identify post-translational modifications (PTMs) in lysine-rich proteins and novel cell surface proteins of R. rickettsii.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Markoutsa, S., Bahr, U., Papasotiriou, D.G., et al. Sulfo-NHS-SS-biotin derivatization: a versatile tool for MALDI mass analysis of PTMs in lysine-rich proteins. Proteomics 14(6), 659-667 (2014).

    2. Gong, W., Xiong, X., Qi, Y., et al. Identification of novel surface-exposed proteins of Rickettsia rickettsii by affinity purification and proteomics. PLoS One 9(6), e100253 (2014).