A metabolite of selinexor
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(E)-KPT-330

Item No. 39562

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 2-(2-pyrazinyl)hydrazide, (2E)-2-propenoic acid
CAS Number
1421923-86-5
Synonyms
  • KTP-330
  • trans Selinexor
Molecular Formula
C17H11F6N7O
Formula Weight
443.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C(NNC1=NC=CN=C1)/C=C/N2C=NC(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=N2
InChi Code
InChI=1S/C17H11F6N7O/c18-16(19,20)11-5-10(6-12(7-11)17(21,22)23)15-26-9-30(29-15)4-1-14(31)28-27-13-8-24-2-3-25-13/h1-9H,(H,25,27)(H,28,31)/b4-1+
InChi Key
DEVSOMFAQLZNKR-DAFODLJHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $28

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    5 mg

    $76

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    10 mg

    $138

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    25 mg

    $241

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    Product Description

    (E)-KPT-330 is a metabolite of the exportin 1 (XPO1/CRM1) inhibitor selinexor.1 It is formed from selinexor by the cytochrome P450 (CYP) isoform CYP3A4.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mancuso, J. Selinexor (Xpovio), an XPO1 inhibitor and a new class of therapeutics for treating multiple myeloma. Current Drug Synthesis 253-264 (2023).