An antiviral agent
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Maribavir

Item No. 39650

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,6-dichloro-N -(1-methylethyl)-1-β-L-ribofuranosyl-1H-benzimidazol-2-amine
CAS Number
176161-24-3
Synonyms
  • BW 1263W94
  • GW 257406X
  • MBV
Molecular Formula
C15H19Cl2N3O4
Formula Weight
376.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: Soluble
SMILES
O[C@@H]1[C@@H](N2C3=CC(Cl)=C(C=C3N=C2NC(C)C)Cl)O[C@@H](CO)[C@@H]1O
InChi Code
InChI=1S/C15H19Cl2N3O4/c1-6(2)18-15-19-9-3-7(16)8(17)4-10(9)20(15)14-13(23)12(22)11(5-21)24-14/h3-4,6,11-14,21-23H,5H2,1-2H3,(H,18,19)/t11-,12-,13-,14-/m0/s1
InChi Key
KJFBVJALEQWJBS-XUXIUFHCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $109

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    10 mg

    $207

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    25 mg

    $491

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    50 mg

    $818

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    Product Description

    Maribavir is an antiviral agent.1 It inhibits human cytomegalovirus (CMV) pUL97 protein kinase (IC50 = 3 nM). Maribavir inhibits the replication of clinical isolates of CMV, including those resistant to ganciclovir (Item No. 37487), in infected MRC-5 human lung fibroblasts (IC50s = 0.03-0.13 µM). Oral administration of maribavir (25 or 75 mg/kg) decreases CMV titers in a mouse model of ocular CMV infection following implantation of human fetal retinal tissue.2 Formulations containing maribavir have been used in the treatment of post-transplant CMV infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Biron, K.K., Harvey, R.J., Chamberlain, S.C., et al. Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action. Antimicrob. Agents Chemother. 46(8), 2365-2372 (2002).

    2. Kern, E.R., Hartline, C.B., Rybak, R.J., et al. Activities of benzimidazole D- and L-ribonucleosides in animal models of cytomegalovirus infections. Antimicrob. Agents Chemother. 48(5), 1749-1755 (2004).