An antifibrotic agent
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Fluorofenidone

Item No. 39651

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(3-fluorophenyl)-5-methyl-2(1H)-pyridinone
CAS Number
848353-85-5
Synonyms
  • AKF-PD
Molecular Formula
C12H10FNO
Formula Weight
203.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: Soluble
SMILES
O=C1C=CC(C)=CN1C2=CC=CC(F)=C2
InChi Code
InChI=1S/C12H10FNO/c1-9-5-6-12(15)14(8-9)11-4-2-3-10(13)7-11/h2-8H,1H3
InChi Key
JDZYVVUJIQYGRX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $65

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    10 mg

    $117

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    25 mg

    $212

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    50 mg

    $325

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    Product Description

    Fluorofenidone is an antifibrotic agent and a derivative of pirfenidone (Item No. 13986).1,2 It inhibits angiotensin II-induced increases in TGF-β1 secretion and reactive oxygen species (ROS) production, as well as TGF-β1-induced production of collagen I, in NRK-52E rat proximal tubular epithelial cells when used at a concentration of 8 mM.1 Fluorofenidone (500 mg/kg) decreases disease severity and the renal levels of collagen I, collagen III, and connective tissue growth factor (CTGF) in a rat model of obstructive nephropathy induced by unilateral ureteral obstruction.2 Fluorofenidone also increases survival in a mouse model of LPS-induced endotoxemia when administered at a dose of 200 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Peng, Z.Z., Hu, G.Y., Shen, H., et al. Fluorofenidone attenuates collagen I and transforming growth factor-β1 expression through a nicotinamide adenine dinucleotide phosphate oxidase-dependent way in NRK-52E cells. Nephrology (Carlton) 14(6), 565-572 (2009).

    2. Li, B.-X., Tang, Y.-T., Wang, W., et al. Fluorofenidone attenuates renal interstitial fibrosis in the rat model of obstructive nephropathy. Mol. Cell. Biochem. 354(1-2), 263-273 (2011).

    3. Tang, Y., Li, B., Wang, N., et al. Fluorofenidone protects mice from lethal endotoxemia through the inhibition of TNF-α and IL-1β release. Int. Immunopharmacol. 10(5), 580-583 (2010).