An inhibitor of PIKfyve
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MOMIPP

Item No. 39671

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one
CAS Number
1363421-46-8
Molecular Formula
C18H16N2O2
Formula Weight
292.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleDMSO: SolubleMethanol: Slightly soluble
SMILES
COC1=CC=C2NC(C)=C(/C=C/C(C3=CC=NC=C3)=O)C2=C1
InChi Code
InChI=1S/C18H16N2O2/c1-12-15(4-6-18(21)13-7-9-19-10-8-13)16-11-14(22-2)3-5-17(16)20-12/h3-11,20H,1-2H3/b6-4+
InChi Key
UPJCYXIOWHZRLU-GQCTYLIASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $42

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    100 mg

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    250 mg

    $147

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    500 mg

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    Product Description

    MOMIPP is an inhibitor of PIKfyve (IC50 = 5.05 nM).1 It selectively binds to PIKfyve over phosphatidylinositol 4-phosphate 5-kinase type-1 γ (PIP5K1C; Kds = 5.3 and >15,000 nM, respectively). MOMIPP (10 µM) induces vacuolization and cell lysis, markers of methuosis, and decreases the extracellular acidification rate (ECAR), indicating inhibition of glycolytic flux, but not the oxygen consumption rate (OCR), in U251 glioblastoma cells.2 Intraperitoneal administration of MOMIPP (80 mg/kg) decreases tumor growth in a U251 orthotopic mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cho, H., Geno, E., Patoor, M., et al. Indolyl-pyridinyl-propenone-induced methuosis through the inhibition of PIKFYVE. ACS Omega 3(6), 6097-6103 (2018).

    2. Li, Z., Mbah, N.E., Overmeyer, J.H., et al. The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma. BMC Cancer 19(1), 77 (2019).