An FPR antagonist
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Boc-FLFLF

Item No. 39673

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-leucyl-L-phenylalanine
CAS Number
73572-58-4
Synonyms
  • Boc-Phe-Leu-Phe-Leu-Phe
  • Boc-PLPLP
  • L-BOC-2
Molecular Formula
C44H59N5O8
Formula Weight
786.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
Boc-FLFLF-OH
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly soluble: 0.1-1 mg/mlMethanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CC1=CC=CC=C1)=O)[C@@H](NC([C@H](CC(C)C)NC([C@@H](NC(OC(C)(C)C)=O)CC2=CC=CC=C2)=O)=O)CC3=CC=CC=C3
InChi Code
InChI=1S/C44H59N5O8/c1-28(2)23-33(46-41(53)36(26-31-19-13-9-14-20-31)49-43(56)57-44(5,6)7)38(50)47-35(25-30-17-11-8-12-18-30)40(52)45-34(24-29(3)4)39(51)48-37(42(54)55)27-32-21-15-10-16-22-32/h8-22,28-29,33-37H,23-27H2,1-7H3,(H,45,52)(H,46,53)(H,47,50)(H,48,51)(H,49,56)(H,54,55)/t33-,34-,35-,36-,37-/m0/s1
InChi Key
NGNZQSPFQJCBJQ-LTLCPEALSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Boc-FLFLF is a formyl peptide receptor (FPR) antagonist (Ki = 1.46 µM).1 It inhibits increases in intracellular calcium levels, superoxide formation, and β-glucuronidase release induced by the FPR agonist N-formyl-Met-Leu-Phe (fMLP; Item No. 21495) in differentiated HL-60 cells (Kis = 0.43, 1.04, and 1.82 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wenzel-Seifert, K., and Siefert, R. Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E. J. Immunol. 150(10), 4591-4599 (1993).