A bile acid derivative
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A17

Item No. 39686

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3α,5β,7β)-3,7-bis(formyloxy)-N-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-cholan-24-amide
CAS Number
2568186-47-8
Molecular Formula
C31H51NO6
Formula Weight
533.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: Sparingly soluble: 1-10 mg/mlMethanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=CO[C@@H]1[C@]2([H])[C@@](CC[C@]3([C@@]2([H])CC[C@]3([H])[C@@H](CCC(N[C@H](CO)C(C)C)=O)C)C)([H])[C@@]4([C@](C[C@@H](CC4)OC=O)([H])C1)C
InChi Code
InChI=1S/C31H51NO6/c1-19(2)26(16-33)32-28(36)9-6-20(3)23-7-8-24-29-25(11-13-31(23,24)5)30(4)12-10-22(37-17-34)14-21(30)15-27(29)38-18-35/h17-27,29,33H,6-16H2,1-5H3,(H,32,36)/t20-,21+,22-,23-,24+,25+,26-,27+,29+,30+,31-/m1/s1
InChi Key
RURKBKWBYCPAPK-WMDVUDLISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $108

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    50 mg

    $205

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    100 mg

    $389

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    250 mg

    $809

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    A17 is a bile acid derivative.1 It reduces triglyceride accumulation induced by oleic acid (Item Nos. 90260 | 24659), increases cell viability, and decreases oleic acid-induced lipid peroxidation in primary rat hepatocytes when used at concentrations of 10 and 25 µM. A17 (25 µM) reduces levels of CD36, also known as scavenger receptor B2 or fatty acid translocase, in primary rat hepatocytes. In vivo, A17 (50 mg/kg) reduces serum triglyceride, total cholesterol, and LDL levels, reverses hepatic steatosis, and decreases hepatic triglyceride, but not total cholesterol, levels in a hamster model of high-fat diet-induced non-alcoholic steatohepatitis (NASH).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, Y., Zhu, Y., Niu, J., et al. A novel bile acid analog, A17, ameliorated non-alcoholic steatohepatitis in high-fat diet-fed hamsters. Toxicol. Appl. Pharmacol. 404, 115169 (2020).