A peptide antibiotic and a major constituent of colistin
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Polymyxin E1 (sulfate)

Item No. 39718

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-(6-methyl-1-oxooctyl)-L-2,4-diaminobutanoyl-L-threonyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-D-leucyl-L-leucyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-L-threonine, cyclic (10→4)-peptide, sulfate
CAS Number
207990-63-4
Synonyms
  • Colistin A sulfate
Molecular Formula
C53H100N16O13 • XH2SO4
Formula Weight
1169.5
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
NCC[C@@H](C(N[C@H]1CCNC([C@@]([C@H](O)C)([H])NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC1=O)CCN)=O)CC(C)C)=O)CC(C)C)=O)CCN)=O)CCN)=O)=O)=O)NC([C@H]([C@H](O)C)NC([C@@H](NC(CCCC[C@@H](C)CC)=O)CCN)=O)=O.O=S(O)(O)=O
InChi Code
InChI=1S/C53H100N16O13.H2O4S/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;1-5(2,3)4/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);(H2,1,2,3,4)/t30-,31+,32+,33-,34-,35-,36-,37-,38-,39-,40+,42-,43-;/m0./s1
InChi Key
ZJIWRHLZXQPFAD-OQPNQKQZSA-N
Origin
Bacterium/Bacillus polymyxa var. colistinus
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Polymyxin E1 is a peptide antibiotic and a major constituent of the cationic lipopeptide antibiotic colistin (Item No. 17584) originally isolated from B. polymyxa.1 It is active against P. aeruginosa and E. coli (MICs = 2 and 0.8 µg/ml, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kline, T., Holub, D., Therrien, J., et al. Synthesis and characterization of the colistin peptide polymyxin E1 and related antimicrobial peptides. J. Pept. Res. 57(3), 175-187 (2001).