A peptide antibiotic and a major constituent of colistin
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Polymyxin E2 (sulfate)

Item No. 39721

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(2S)-4-amino-2-[(6-methyl-1-oxoheptyl)amino]butanoic acid]-polymyxin E1, sulfate
CAS Number
1338055-88-1
Synonyms
  • Colistin B sulfate
Molecular Formula
C52H98N16O13 • XH2SO4
Formula Weight
1155.4
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
NCC[C@@H](C(N[C@H]1CCNC([C@@]([C@H](O)C)([H])NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC1=O)CCN)=O)CC(C)C)=O)CC(C)C)=O)CCN)=O)CCN)=O)=O)=O)NC([C@H]([C@H](O)C)NC([C@@H](NC(CCCCC(C)C)=O)CCN)=O)=O.O=S(O)(O)=O
InChi Code
InChI=1S/C52H98N16O13.H2O4S/c1-27(2)11-9-10-12-40(71)59-32(13-19-53)47(76)68-42(31(8)70)52(81)64-35(16-22-56)44(73)63-37-18-24-58-51(80)41(30(7)69)67-48(77)36(17-23-57)61-43(72)33(14-20-54)62-49(78)38(25-28(3)4)66-50(79)39(26-29(5)6)65-45(74)34(15-21-55)60-46(37)75;1-5(2,3)4/h27-39,41-42,69-70H,9-26,53-57H2,1-8H3,(H,58,80)(H,59,71)(H,60,75)(H,61,72)(H,62,78)(H,63,73)(H,64,81)(H,65,74)(H,66,79)(H,67,77)(H,68,76);(H2,1,2,3,4)/t30-,31-,32+,33+,34+,35+,36+,37+,38+,39-,41+,42+;/m1./s1
InChi Key
XYXFTCPJFHFTTO-KSPURPISSA-N
Origin
Bacterium/Bacillus polymyxa var. colistinus
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $448

    Add

    1 mg

    $673

    Add
    Product Description

    Polymyxin E2 is a peptide antibiotic and a major constituent of the cationic lipopeptide antibiotic colistin (Item No. 17584) originally isolated from B. polymyxa.1 It is active against the plant pathogenic bacteria X. oryzae (EC50 = 0.21 µg/ml) and prevents and reverses rice bacterial leaf blight in greenhouse studies when applied at a concentration of 200 µg/ml.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Suzuki, T., Inouye, H., Fujikawa, K., et al. Studies on the chemical structure of colistin. I. Fractionation, molecular weight determination, amino acid and fatty acid composition. J. Biochem. 54(1), 25-33 (1963).

    2. Yi, W., Chen, C., and Gan, X. Polymyxin B1 and E2 from Paenibacillus polymyxa Y-1 for controlling rice bacterial disease. Front. Cell. Infect. Microbiol. 12:866357, (2022).