A GAL1 and GAL2 receptor modulator
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M40 (trifluoroacetate salt)

Item No. 39726

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-prolyl-L-prolyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-alaninamide, trifluoroacetate salt
Synonyms
  • Galanin-(1-12)-Pro3-(Ala-Leu)2-Ala amide
Molecular Formula
C94H145N23O24 • XCF3COOH
Formula Weight
1981.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
GYTLNSAGYLLGPPPALALA-NH2
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
[H]NCC(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(N1CCC[C@H]1C(N2CCC[C@H]2C(N3CCC[C@H]3C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)C)=O)=O)C)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)CC4=CC=C(O)C=C4)=O)=O)C)=O)=O)=O)=O)=O)CC5=CNC6=C5C=CC=C6)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C94H145N23O24.C2HF3O2/c1-46(2)33-61(82(129)100-44-76(124)115-30-19-24-71(115)93(140)117-32-20-25-72(117)94(141)116-31-18-23-70(116)91(138)104-54(14)81(128)108-63(35-48(5)6)84(131)103-53(13)80(127)107-62(34-47(3)4)83(130)101-51(11)78(97)125)109-85(132)64(36-49(7)8)110-87(134)66(38-56-26-28-58(120)29-27-56)106-75(123)43-99-79(126)52(12)102-90(137)69(45-118)113-88(135)68(40-73(96)121)111-86(133)65(37-50(9)10)112-92(139)77(55(15)119)114-89(136)67(105-74(122)41-95)39-57-42-98-60-22-17-16-21-59(57)60;3-2(4,5)1(6)7/h16-17,21-22,26-29,42,46-55,61-72,77,98,118-120H,18-20,23-25,30-41,43-45,95H2,1-15H3,(H2,96,121)(H2,97,125)(H,99,126)(H,100,129)(H,101,130)(H,102,137)(H,103,131)(H,104,138)(H,105,122)(H,106,123)(H,107,127)(H,108,128)(H,109,132)(H,110,134)(H,111,133)(H,112,139)(H,113,135)(H,114,136);(H,6,7)/t51-,52-,53-,54-,55+,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,77-;/m0./s1
InChi Key
FRCHWUHLLBJWIS-NKMYXGHHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $162

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    1 mg

    $307

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    5 mg

    $1,052

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    Product Description

    M40 is a chimeric galanin-derived peptide and galanin-1 (GAL1) receptor antagonist and GAL2 receptor agonist (Kis = 2.4 and 4.07 nM, respectively).1,2 It is selective for the GAL1 and GAL2 receptors over the GAL3 receptor (Ki = 288 nM).1 M40 induces inositol phosphate accumulation in CHO cells expressing the human GAL2 receptor (EC50 = 16.2 nM) and inhibits forskolin-induced cAMP accumulation in RIN-m5F pancreatic β-cells when used at concentrations of 10 or 100 nM.1,2 In vivo, M40 (9.36 nmol/animal, i.c.v.) reverses galanin-induced inhibition of scopolamine-induced hippocampal acetylcholine (ACh) release in conscious rats.2 M40 reduces galanin-induced increases in food intake in rats. It improves cardiac function and decreases cardiac fibrosis in a rat model of heart failure induced by sustained coronary artery ligation when administered at a dose of 30 nmol/kg.3 M40 (20 µg/animal) increases the intromission frequency and ejaculation latency in sexually sluggish male mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Borowsky, B., Walker, M.W., Huang, L.Y., et al. Cloning and characterization of the human galanin GALR2 receptor. Peptides 19(10), 1771-1781 (1998).

    2. Bartfai, T., Langel, Ü., Bedecs, K., et al. Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Proc. Natl. Acad. Sci. USA 90(23), 11287-11291 (1993).

    3. Chen, A., Li, M., Song, L., et al. Effects of the galanin receptor antagonist M40 on cardiac function and remodeling in rats with heart failure. Cardiovasc. Ther. 33(5), 288-293 (2015).

    4. Benelli, A., Bertolini, A., Zoli, M., et al. Pharmacological manipulation of brain galaninergic system and sexual behavior in male mice. Psychopharmacology (Berl) 160(3), 325-330 (2002).