An inhibitor of αVβ5 integrin
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αvβ5 Integrin-IN-1

Item No. 39733

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(βS,3R)-γ-oxo-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-β-[3-(trifluoromethyl)phenyl]-1-pyrrolidinebutanoic acid
CAS Number
2615912-33-7
Synonyms
  • αvβ5 Integrin Inhibitor 1
Molecular Formula
C25H28F3N3O3
Formula Weight
475.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Soluble
SMILES
O=C([C@@H](CC(O)=O)C1=CC(C(F)(F)F)=CC=C1)N2CC[C@@H](CCC(N3)=CC=C4C3=NCCC4)C2
InChi Code
InChI=1S/C25H28F3N3O3/c26-25(27,28)19-5-1-3-18(13-19)21(14-22(32)33)24(34)31-12-10-16(15-31)6-8-20-9-7-17-4-2-11-29-23(17)30-20/h1,3,5,7,9,13,16,21H,2,4,6,8,10-12,14-15H2,(H,29,30)(H,32,33)/t16-,21+/m1/s1
InChi Key
NUPIGKKRXBENIY-IERDGZPVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $327

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    Product Description

    αvβ5 Integrin-IN-1 is an inhibitor of αVβ5 integrin (IC50 = 0.0063 µM).1 It is selective for αVβ5 over αVβ1, αVβ3, αVβ6, and αVβ8 (IC50s = 2.51, 5.01, 50.1, and 50.1 µM, respectively). αvβ5 Integrin-IN-1 inhibits adhesion of αVβ5-expressing K562 cells to vitronectin-coated plates.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lippa, R.A., Barrett, J., Pal, S., et al. Discovery of the first potent and selective αvβ5 integrin inhibitor based on an amide-containing core. Eur. J. Med. Chem. 208, 112719 (2020).