A PARP1 and PARP2 inhibitor
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YCH1899

Item No. 39737

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[3-[[3-(5-bromo-2-furanyl)-5,6-dihydro-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone
CAS Number
3032451-66-1
Molecular Formula
C25H18BrFN6O3
Formula Weight
549.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C1NN=C(CC2=CC=C(F)C(C(N3CCN4C(C3)=NN=C4C5=CC=C(Br)O5)=O)=C2)C6=CC=CC=C61
InChi Code
InChI=1S/C25H18BrFN6O3/c26-21-8-7-20(36-21)23-30-29-22-13-32(9-10-33(22)23)25(35)17-11-14(5-6-18(17)27)12-19-15-3-1-2-4-16(15)24(34)31-28-19/h1-8,11H,9-10,12-13H2,(H,31,34)
InChi Key
STSCRAGBCYODMY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

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    10 mg

    $486

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    Product Description

    YCH1899 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = <0.001 nM for both).1 It is selective for PARP1 and PARP2 over PARP3, -4, -5A, -5B, -6, -7, -10, and -12 (IC50s = 1-14.1 nM). YCH1899 inhibits the proliferation of Capan-1 cells (IC50 = 0.1 nM), as well as Capan-1 cells resistant to the PARP inhibitors talazoparib (BMN 673; Item No. 19782) or olaparib (Item No. 10621; IC50s = 1.13 and 0.89 nM, respectively). It inhibits the proliferation of BRCA1 mutant HCC1937 breast cancer cells (IC50 = 4.54 nM). In vivo, YCH1899 (12.5 and 25 mg/kg) reduces tumor growth in an olaparib-resistant MDA-MB-436 breast cancer mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sun, Y., Yang, H., Yuan, J., et al. YCH1899, a highly effective phthalazin-1(2H)-one derivative that overcomes resistance to prior PARP inhibitors. J. Med. Chem. 66(17), 12284-12303 (2023).