An ionizable cationic lipid
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Lipid 331

Item No. 39771

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
di((9Z,12Z)-octadeca-9,12-dien-1-yl) 4,4'-(2-(tert-butoxycarbonyl)-1-(2-(2-ethylpiperidin-1-yl)ethyl)-2,5-dihydro-1H-imidazole-5,5-diyl)dibutyrate
Molecular Formula
C61H107N3O6
Formula Weight
978.5
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleMethanol: Soluble
SMILES
O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCCC1(CCCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)C=NC(C(OC(C)(C)C)=O)N1CCN2CCCCC2CC
InChi Code
InChI=1S/C61H107N3O6/c1-7-10-12-14-16-18-20-22-24-26-28-30-32-34-36-40-52-68-56(65)45-42-47-61(54-62-58(59(67)70-60(4,5)6)64(61)51-50-63-49-39-38-44-55(63)9-3)48-43-46-57(66)69-53-41-37-35-33-31-29-27-25-23-21-19-17-15-13-11-8-2/h16-19,22-25,54-55,58H,7-15,20-21,26-53H2,1-6H3/b18-16-,19-17-,24-22-,25-23-
InChi Key
UGSRIRFHGLQYBQ-HBZIWDQGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $138

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    5 mg

    $585

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    10 mg

    $1,032

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    Cayman Chemical
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    Product Description

    Lipid 331 is a biodegradable cyclic ionizable cationic lipid (pKa = 7.53) that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing lipid 331 and encapsulating 5-methoxyuridine-modified mRNA encoding ovalbumin induce IFN regulatory factor (IRF) activation in a reporter assay using THP-1 monocytes. Intranasal administration of LNPs containing lipid 331 and DOTAP (Item Nos. 15110 | 38905) and encapsulating mRNA encoding a fusion of the receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein, also known as surface glycoprotein, with mouse complement C3d as an adjuvant increase serum anti-SARS-CoV-2 spike glycoprotein RBD IgG titers in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, B., Jiang, A.Y., Raji, I., et al. Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA. Nat. Biomed. Eng. (2023).