A μ-, κ1-, and δ-opioid receptor antagonist
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Naloxone benzoylhydrazone

Item No. 39827

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(5α)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)ylidene]hydrazide, benzoic acid
CAS Number
119630-94-3
Molecular Formula
C26H27N3O4
Formula Weight
445.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O[C@@]1(CC2)[C@@]([C@](O3)([H])C2=NNC(C4=CC=CC=C4)=O)(CC5)C(C3=C6O)=C(C=C6)C[C@@]1([H])N5CC=C
InChi Code
InChI=1S/C26H27N3O4/c1-2-13-29-14-12-25-21-17-8-9-19(30)22(21)33-23(25)18(10-11-26(25,32)20(29)15-17)27-28-24(31)16-6-4-3-5-7-16/h2-9,20,23,30,32H,1,10-15H2,(H,28,31)/t20-,23+,25+,26-/m1/s1
InChi Key
AKXCFAYOTIEFOH-RTOPKKFASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    Naloxone benzoylhydrazone is an antagonist of μ-, κ1-, and δ-opioid receptors (pA2s = 8.82, 7.45, and 7.76, respectively, for the mouse receptors).1 It is also an agonist of the κ3-opioid receptor (IC50 = 0.7 nM for the guinea pig receptor). Naloxone benzoylhydrazone (1 µg/animal, i.c.v.) inhibits increases in the latency to tail withdrawal induced by the μ-opioid receptor agonist DAMGO (Item No. 21553) in a hot plate assay in mice.2 It increases food intake in rats when intracerebrally administered at doses of 0.1, 1, and 20 µg/animal.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Berzetei-Gurske, I.P., White, A., Polgar, W., et al. The in vitro pharmacological characterization of naloxone benzoylhydrazone. Eur. J. Pharmacol. 277(2-3), 257-263 (1995).

    2. Paul, D., Levison, J.A., Howard, D.H., et al. Naloxone benzoylhydrazone (NalBzoH) analgesia. J. Pharmacol. Exp. Ther. 255(2), 769-774 (1990).

    3. Koch, J.E., Pasternak, G.W., Arjune, D., et al. Naloxone benzoylhydrazone, a ᴋ3 opioid agonist, stimulates food intake in rats. Brain. Res. 581(2), 311-314 (1992).