An irreversible STING antagonist
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LB244

Item No. 39832

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(R)-N-(4-([1,1'-biphenyl]-4-carboxamido)-4-(1H-benzo[d]imidazol-2-yl)butyl)-5-nitrofuran-2-carboxamide
Molecular Formula
C29H25N5O5
Formula Weight
523.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Soluble
SMILES
O=C(N[C@@H](C1=NC(C=CC=C2)=C2N1)CCCNC(C3=CC=C([N+]([O-])=O)O3)=O)C(C=C4)=CC=C4C5=CC=CC=C5
InChi Code
InChI=1S/C29H25N5O5/c35-28(21-14-12-20(13-15-21)19-7-2-1-3-8-19)33-24(27-31-22-9-4-5-10-23(22)32-27)11-6-18-30-29(36)25-16-17-26(39-25)34(37)38/h1-5,7-10,12-17,24H,6,11,18H2,(H,30,36)(H,31,32)(H,33,35)/t24-/m1/s1
InChi Key
PQGNTDYYMHGKPA-XMMPIXPASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    LB244 is an irreversible STING antagonist.1 It binds to STING in a cell-free assay and inhibits STING activation induced by the STING agonist diABZI in cells (EC50 = 0.8 nM). LB244 (1 µM) inhibits diABZI-induced STING oligomerization and phosphorylation of IFN regulatory factor 3 (IRF3) and TANK-binding kinase 1 (TBK1) in primary mouse bone marrow-derived macrophages (BMDMs). In vivo, LB244 (5 mg/kg, i.p.) reduces diABZI-induced increases in serum IL-6 and IFN-β levels in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Barasa, L., Chaudhuri, S., Zhou, J.Y., et al. Development of LB244, an irreversible STING antagonist. J. Am. Chem. Soc. 145(37), 20273-20288 (2023).