An internal standard for the quantification of cyclobenzaprine
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Cyclobenzaprine-d6 (hydrochloride)

Item No. 39834

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-d3-1-propanamine, monohydrochloride
CAS Number
2748492-38-6
Synonyms
  • MK-130-d6
Molecular Formula
C20H15D6N • HCl
Formula Weight
317.9
Purity
≥99% deuterated forms (d1-d6)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
[2H]C([2H])([2H])N(C([2H])([2H])[2H])CC/C=C1C2=C(C=CC=C2)C=CC3=C/1C=CC=C3.Cl
InChi Code
InChI=1S/C20H21N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-14H,7,15H2,1-2H3;1H/i1D3,2D3;
InChi Key
VXEAYBOGHINOKW-TXHXQZCNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $348

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    Product Description

    Cyclobenzaprine-d6 is intended for use as an internal standard for the quantification of cyclobenzaprine by GC- or LC-MS. Cyclobenzaprine is a skeletal muscle relaxant.1,2,3 It is an antagonist of M1, M2, and M3 muscarinic acetylcholine receptors (mAChRs; Kis = 25, 60, and 6 nM, respectively), the histamine H1 receptor (IC50 = 20 nM), and serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2B, and 5-HT2C (Kis = 1,685, 330, and 56 nM, respectively). Cyclobenzaprine (1 mg/kg) prevents increases in the flexor reflex induced by the 5-HT2 receptor agonist DOI in spinalized rats.3 Formulations containing cyclobenzaprine have been used as muscle relaxants.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gregori-Puigjané, E., Setola, V., Hert, J., et al. Identifying mechanism-of-action targets for drugs and probes. Proc. Natl. Acad. Sci. USA 109(28), 11178-11183 (2012).

    2. Lounkine, E., Keiser, M.J., Whitebread, S., et al. Large scale prediction and testing of drug activity on side-effect targets. Nature 486(7403), 361-367 (2012).

    3. Honda, M., Nishida, T., and Ono, H. Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT2 receptors. Eur. J. Pharmacol. 458(1-2), 91-99 (2003).