A RIPK3 inhibitor
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GSK843

Item No. 39835

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(5-benzothiazolyl)-7-(1,3-dimethyl-thieno[3,2-c]pyridin-4-amine
CAS Number
1601496-05-2
Molecular Formula
C19H15N5S2
Formula Weight
377.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly SolubleDMSO: SolubleMethanol: Slightly Soluble
SMILES
NC1=C2C(C3=CC4=C(SC=N4)C=C3)=CSC2=C(C5=CC(C)=NN5C)C=N1
InChi Code
InChI=1S/C19H15N5S2/c1-10-5-15(24(2)23-10)12-7-21-19(20)17-13(8-25-18(12)17)11-3-4-16-14(6-11)22-9-26-16/h3-9H,1-2H3,(H2,20,21)
InChi Key
BPKSNNJTKPIZKR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $31

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    5 mg

    $108

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    10 mg

    $154

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    25 mg

    $270

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    Product Description

    GSK843 is an inhibitor of receptor-interacting serine/threonine kinase 3 (RIPK3; IC50 = 6.5 nM).1 It is selective for RIPK3 over a panel of 300 additional kinases at 1 µM. GSK843 (10 µM) induces apoptosis in L-929 fibroblasts. It inhibits TNF-α-induced necroptosis in primary human neutrophils in a concentration-dependent manner. GSK843 (3 µM) also inhibits necrosis induced by the toll-like receptor 3 (TLR3) agonist poly (I:C) in IFN-β-primed 3T3-SA fibroblasts.2 Intrathecal administration of GSK843 (5 µl of a 13 mM solution) increases the paw withdrawal threshold and latency in a mouse model of inflammatory pain induced by complete Freund’s adjuvant.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mandal, P., Berger, S.B., Pillay, S., et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol. Cell 56(4), 481-495 (2014).

    2. Kaiser, W.J., Sridharan, H., Huang, C., et al. Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. The Journal of Biological Chemisty 288(43), 31268-31279 (2013).

    3. Zhang , Y., Wang, Y., Zhao, W., et al. Role of spinal RIP3 in inflammatory pain and electroacupuncture-mediated analgesic effect in mice. Life Sci. 306, 120839 (2022).