An anticancer agent
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Cell Death
Multidrug Resistance

HR68

Item No. 39855

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-N-4-pyridinyl-propanamide
CAS Number
2454582-64-8
Synonyms
  • PP21
Molecular Formula
C22H19ClN2O3
Formula Weight
394.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleChloroform: SolubleMethanol: Soluble
SMILES
CC(C(NC1=CC=NC=C1)=O)(OC2=CC=C(C(C3=CC=C(C=C3)Cl)=O)C=C2)C
InChi Code
InChI=1S/C22H19ClN2O3/c1-22(2,21(27)25-18-11-13-24-14-12-18)28-19-9-5-16(6-10-19)20(26)15-3-7-17(23)8-4-15/h3-14H,1-2H3,(H,24,25,27)
InChi Key
UUBDTDNTOJQKPE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $28

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    5 mg

    $131

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    10 mg

    $248

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    50 mg

    $1,032

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    Cayman Chemical
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    Product Description

    HR68 is an anticancer agent and a derivative of the peroxisome proliferator-activated receptor (PPAR) agonist fenofibric acid (Item No. 19262).1 It decreases the viability of LN-229 glioblastoma cells (IC50 = 1.17 µM). HR68 crosses the blood-brain barrier in a temozolomide-resistant orthotopic patient-derived xenograft (PDX) mouse model of glioblastoma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ingraham, C.H., 4th., Stalinska, J., Carson, S.C., et al. Computational modeling and synthesis of pyridine variants of benzoyl-phenoxy-acetamide with high glioblastoma cytotoxicity and brain tumor penetration. Sci. Rep. 13(1), 12235 (2023).